Acrodermatitis enteropathica
Acrodermatitis Enteropathica
Acrodermatitis enteropathica (pronounced as ak-roh-der-muh-tahy-tis en-ter-uh-path-i-kuh) is a rare inherited disorder that affects the absorption of zinc in the body. The term is derived from the Greek words 'akron' meaning extremity, 'derma' meaning skin, and 'enteron' meaning intestine, and 'pathos' meaning suffering.
Symptoms
The symptoms of acrodermatitis enteropathica usually appear within the first few months of life and may include skin inflammation, hair loss, diarrhea, and failure to thrive. The skin lesions are typically around the mouth, anus, and hands, but can also occur on other parts of the body.
Causes
Acrodermatitis enteropathica is caused by mutations in the SLC39A4 gene. This gene provides instructions for making a protein that is involved in the absorption of zinc from the diet. Mutations in the SLC39A4 gene disrupt the normal absorption of zinc, leading to a zinc deficiency that is responsible for the symptoms of acrodermatitis enteropathica.
Treatment
Treatment for acrodermatitis enteropathica involves lifelong supplementation with zinc. With proper treatment, the symptoms of the disorder can be managed effectively.
Related Terms
See Also
External links
- Medical encyclopedia article on Acrodermatitis enteropathica
- Wikipedia's article - Acrodermatitis enteropathica
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