Sporotrichosis

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Sporotrichosis
File:Feline sporotrichosis 4.jpg A cat with sporotrichosis
Synonyms	Rose gardener's disease
Pronounce	N/A
Specialty	N/A
Symptoms	Skin lesions, ulcers, lymph node swelling
Complications	Disseminated infection
Onset	1 to 12 weeks after exposure
Duration	Weeks to months
Types	N/A
Causes	Sporothrix schenckii complex
Risks	Handling soil, plants, sphagnum moss
Diagnosis	Culture, biopsy
Differential diagnosis	Cutaneous leishmaniasis, mycobacterial infection
Prevention	Protective clothing, avoiding exposure
Treatment	Itraconazole, amphotericin B
Medication	Antifungals
Prognosis	Generally good with treatment
Frequency	Common in tropical and subtropical areas
Deaths	N/A

Sporotrichosis is an infection with a fungus acquired through a skin wound; causes an ulcer at the site of infection and small, rounded masses of tissue near it.

Sporotrichosis by the fungus Sporothrix schenckii

Pathophysiology

Sporotrichosis (also known as “rose gardener’s disease”) is an infection caused by a fungus called Sporothrix.

Habitat

This fungus lives throughout the world in soil and on plant matter such as sphagnum moss, rose bushes, and hay.

Source of infection

People get sporotrichosis by coming in contact with the fungal spores in the environment. Cutaneous (skin) infection is the most common form of the infection. It occurs when the fungus enters the skin through a small cut or scrape, usually after someone touches contaminated plant matter. Skin on the hands or arms is most commonly affected.

Types of sporotrichosis

Cutaneous (skin) sporotrichosis is the most common form of the infection. It usually occurs on a person’s hand or the arm after touching contaminated plant matter. Pulmonary (lung) sporotrichosis is rare but can happen after someone breathes in fungal spores from the environment. Disseminated sporotrichosis occurs when the infection spreads to another part of the body, such as bones, joints, or central nervous system. This form of sporotrichosis usually affects people with health problems or who take medicines that lower the body’s ability to fight germs and sickness, such as people living with HIV.

Other forms: Sporothrix brasiliensis

Sporothrix brasiliensis is a fungus that is increasingly causing disease in cats and people in Brazil and parts of South America.

Symptoms

The symptoms of sporotrichosis depend on where the fungus is growing in the body. Contact your healthcare provider if you have symptoms that you think are related to sporotrichosis. Sporotrichosis usually affects the skin or tissues underneath the skin. The first symptom of cutaneous (skin) sporotrichosis is usually a small, painless bump that can develop any time from 1 to 12 weeks after exposure to the fungus. The bump can be red, pink, or purple, and usually appears on the finger, hand, or arm where the fungus has entered through a break in the skin. The bump will eventually grow larger and may look like an open sore or ulcer that is very slow to heal. Additional bumps or sores may appear later near the original one. Pulmonary (lung) sporotrichosis is rare. Symptoms include cough, shortness of breath, chest pain, and fever. Symptoms of disseminated sporotrichosis depend on the body part affected. For example, infection of the joints can cause joint pain that may be confused with rheumatoid arthritis. Infections of the central nervous system can involve difficulty thinking, headache, and seizures.

Conidiophores and conidia of the fungus Sporothrix schenckii PHIL

Risk & Prevention

People who touch plant matter such as sphagnum moss, rose bushes, or hay are more likely to become infected. For example, sporotrichosis outbreaks have occurred among forestry workers, people who work in tree nurseries and garden centers, and people who handle hay bales. The severe forms of sporotrichosis (those that affect the lungs, bones or joints, or central nervous system) usually affect people with weakened immune systems or other diseases including diabetes, chronic obstructive pulmonary disease (COPD), alcoholism, or HIV.

Reduce risk

You can lower the chance of getting sporotrichosis by wearing protective clothing such as gloves and long sleeves when touching plant matter that can cause minor cuts or scrapes.

Disseminated sporotrichosis

In Brazil, people have gotten sporotrichosis from contact with cats. This form of sporotrichosis (Sporothrix brasiliensis) has not been found in the United States. Be careful with unfamiliar animals, particularly cats. Cat bites and scratches can spread the fungus that causes sporotrichosis, and other diseases. This fungus is most often spread by stray cats and pet cats that are allowed outdoors. Learn more about sporotrichosis from cats.

Cause

Sporothrix, the fungus that causes sporotrichosis, lives in the environment in soil and on plant matter such as sphagnum moss, rose bushes, hay, or wood. The microscopic fungus can enter the skin through small cuts or scrapes. In rare cases, breathing in the fungus can cause a pulmonary (lung) infection. The type of sporotrichosis found in North America is not contagious and can’t spread from person to person. However, in South America, a type of sporotrichosis caused by Sporothrix brasiliensis spreads through scratches or bites from animals, particularly cats. (This fungal illness is not cat-scratch disease, a bacterial illness spread by cats Рwhich occurs worldwide, wherever cats live.)

Diagnosis & Testing

Your healthcare provider will take a small tissue sample (biopsy) of the infected area of the body for laboratory tests. The laboratory will usually perform a fungal culture to find out what is causing the infection. Blood tests can help diagnose severe sporotrichosis, but usually can’t diagnose skin infections.

Treatment

Most cases of sporotrichosis only involve the skin or the tissues underneath the skin. These infections are not life-threatening, but must be treated with prescription antifungal medicine for several months. The most common treatment for this type of sporotrichosis is itraconazole, taken by mouth for 3 to 6 months. Supersaturated potassium iodide (SSKI) is another treatment option for skin sporotrichosis. SSKI and azole drugs like itraconazole should not be used if you are pregnant. If you have severe sporotrichosis that affects your lungs, bones, joints, or central nervous system, you’ll probably receive intravenous amphotericin B medicine, which is given through a vein. After the first treatment with amphotericin B, you may receive itraconazole by mouth, for a total of at least 1 year of antifungal treatment. People with sporotrichosis in the lungs may also need surgery to cut away the infected tissue.

Gallery

• Buffalo medical journal (1913) (14763713382)
  Buffalo medical journal (1913) (14763713382)
• Buffalo medical journal (1913) (14577583107)
  Buffalo medical journal (1913) (14577583107)
• Sporothrix schenckii PHIL 3943 lores
  Sporothrix schenckii PHIL 3943 lores
• Buffalo medical journal (1913) (14741044226)
  Buffalo medical journal (1913) (14741044226)
• The British journal of dermatology (1888) (14787067013)
  The British journal of dermatology (1888) (14787067013)
• The British journal of dermatology (1888) (14584638947)
  The British journal of dermatology (1888) (14584638947)
• The British journal of dermatology (1888) (14767197045)
  The British journal of dermatology (1888) (14767197045)

• Sporotrichosis by Health in Plain English (with pictures)
• Sporotrichosis by Centers for Disease Control and Prevention (CDC)
• CDC

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