Indium (111In) capromab pendetide

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Indium (111In) capromab pendetide
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CAS Number 151763-64-3
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Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.<ref name="PMID 18279057">, 

 Indium-111 capromab pendetide in the management of recurrent prostate cancer, 
 Expert Review of Anticancer Therapy, 
 2008,
 Vol. 8(Issue: 2),
 pp. 175–81,
 DOI: 10.1586/14737140.8.2.175,
 PMID: 18279057,</ref> Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.<ref>WHO Drug Information</ref> Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single photon emission computed tomography (SPECT).<ref name=" PMID 18279057" />

Early trials with yttrium (90Y) capromab pendetide were also conducted.<ref>Kahn, Daniel, 

 A Phase II Study of [90Y] Yttrium-Capromab Pendetide in the Treatment of Men with Prostate Cancer Recurrence Following Radical Prostatectomy, 
 Cancer Biotherapy & Radiopharmaceuticals, 
 1999,
 Vol. 14(Issue: 2),
 pp. 99,
 DOI: 10.1089/cbr.1999.14.99,</ref>

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Diagnostic radiopharmaceuticals (V09)
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Monoclonal antibodies for tumors
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