Villoglandular adenocarcinoma of the cervix

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Villoglandular adenocarcinoma of the cervix
Villoglandular adenocarcinoma - low mag.jpg
Micrograph of a villoglandular adenocarcinoma the cervix. H&E stain.
Synonyms Villoglandular papillary adenocarcinoma, papillary villoglandular adenocarcinoma, well-differentiated villoglandular adenocarcinoma (VGA)


Specialty Pathology, gynecology

















Villoglandular adenocarcinoma of the cervix is a rare type of cervical cancer that, in relation to other cervical cancers, is typically found in younger women and has a better prognosis.[1]

A similar lesion, villoglandular adenocarcinoma of the endometrium, may arise from the inner lining of the uterus, the endometrium.[2]

Signs and symptoms[edit]

The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.

Cause[edit]


Diagnosis[edit]

The diagnosis is based on tissue examination, e.g. biopsy.

The name of the lesion describes it microscopic appearance. It has nipple-like structures with fibrovascular cores (papillae) that are long in relation to their width (villus-like), which are covered with a glandular pseudostratified columnar epithelium.

  • Very low mag.
    Very low mag.
  • Intermed. mag.
    Intermed. mag.
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    Very high mag.

Treatment[edit]

The treatment is dependent on the stage. As the prognosis of this tumour is usually good, fertility sparing approaches (conization, cervicectomy) may be viable treatment options.

See also[edit]

References[edit]

  1. ↑ "Villoglandular papillary adenocarcinoma of the uterine cervix: a diagnostic challenge.".Acta Obstet Gynecol Scand.2009;88(3)
    355–8.doi:10.1080/00016340902730359.
  2. ↑ "Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study.".Am J Surg Pathol.Nov 1998;22(11)
    1379–85.doi:10.1097/00000478-199811000-00008.

External links[edit]

Tumors of the female urogenital system
Adnexa
Uterus
Vagina
Vulva

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