Sertoli cell tumour

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Sertoli cell tumour
Synonyms	Sertoli cell tumor
Pronounce	N/A
Specialty	N/A
Symptoms	Testicular mass, gynecomastia, infertility
Complications	Metastasis
Onset	Any age, but most common in adults
Duration	Variable
Types	Benign, Malignant
Causes	Unknown
Risks	Genetic syndromes such as Peutz-Jeghers syndrome, Carney complex
Diagnosis	Histopathology, Imaging studies
Differential diagnosis	Leydig cell tumour, Germ cell tumour, Testicular cancer
Prevention	None
Treatment	Surgery, Radiation therapy, Chemotherapy
Medication	N/A
Prognosis	Generally good for benign tumors, variable for malignant
Frequency	Rare
Deaths	N/A

Sertoli cell tumour low magnification

Leydig cell tumour

Leydig cell tumour

Sertoli cell tumour is a type of testicular cancer that originates from the Sertoli cells in the testis. These cells are part of the seminiferous tubules and play a crucial role in spermatogenesis, the process of sperm production.

Introduction

Sertoli cell tumours are rare and account for less than 1% of all testicular cancers. They are usually benign, but in rare cases, they can be malignant. The tumours are often discovered during a physical examination or through imaging tests. Symptoms may include a lump in the testicle, testicular pain or discomfort, and in some cases, gynecomastia (enlargement of male breasts) due to hormonal changes.

Diagnosis

The diagnosis of a Sertoli cell tumour is typically confirmed through a biopsy, where a small sample of the tumour is removed and examined under a microscope. Immunohistochemistry is often used to differentiate Sertoli cell tumours from other types of testicular tumours.

Treatment

The primary treatment for Sertoli cell tumours is surgical removal of the tumour, known as orchiectomy. In some cases, additional treatments such as radiation therapy or chemotherapy may be recommended, particularly if the tumour is malignant or if it has spread to other parts of the body.

Prognosis

The prognosis for individuals with Sertoli cell tumours is generally good, particularly if the tumour is detected early and is benign. However, malignant tumours or those that have spread can be more challenging to treat and may have a poorer prognosis.

See also

• Testicular cancer
• Sertoli cells
• Spermatogenesis
• Orchiectomy

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