RHEB

RHEB (Ras Homolog Enriched in Brain) is a small G protein that is known for its role in regulating the mTOR pathway, which controls cell growth and metabolism in response to nutrients, growth factors, and cellular energy. RHEB is encoded by the RHEB gene in humans.

Function

RHEB is a member of the Ras superfamily of small GTPases. These proteins function as molecular switches, cycling between an inactive GDP-bound state and an active GTP-bound state. RHEB is unique among Ras family members due to its ability to activate the mTORC1 complex, a critical regulator of cell growth and proliferation.

Clinical Significance

Mutations in the RHEB gene have been associated with various diseases, including tuberous sclerosis, a genetic disorder that causes non-cancerous (benign) tumors to grow in many parts of the body. In addition, overexpression of RHEB has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

Research

Research on RHEB has focused on its role in the mTOR pathway and its potential as a therapeutic target in diseases such as cancer and tuberous sclerosis. Inhibition of RHEB has been shown to reduce mTORC1 activity and slow tumor growth in preclinical models.

See Also

• mTOR pathway
• G protein
• Tuberous sclerosis

References

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External links

• Comprehensive information from the National Institute of health.
  

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  GDP bound Rheb

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  GTP bound Rheb

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  RHEB SWITCH II