GPRC5D

GPRC5D (G Protein-Coupled Receptor Class C Group 5 Member D) is a protein that in humans is encoded by the GPRC5D gene. It is a member of the G protein-coupled receptor family, which is a large family of cell surface receptors that respond to various external stimuli and play a crucial role in many physiological processes.

Function

GPRC5D is primarily expressed in the placenta and to a lesser extent in the lung and pancreas. It is also found in multiple myeloma cells. The exact function of GPRC5D is not fully understood, but it is believed to play a role in the regulation of cell growth and differentiation.

Clinical significance

GPRC5D is a potential target for the treatment of multiple myeloma, a type of blood cancer that affects plasma cells. Studies have shown that GPRC5D is highly expressed in multiple myeloma cells, and targeting this receptor with monoclonal antibodies has shown promise in preclinical studies.

Research

Research into the function and potential therapeutic applications of GPRC5D is ongoing. Understanding the role of this receptor in normal physiology and disease could lead to the development of new treatments for multiple myeloma and potentially other diseases.

See also

• G protein-coupled receptor
• Multiple myeloma
• Monoclonal antibodies

References

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GPRC5D

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  GPRC5D complexed with Talquetamab Fab (PDB: 9IMA)