Aprotinin

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Aprotinin

Aprotinin (pronounced: a-pro-ti-nin) is a protein that is used as a medication to control bleeding during complex surgery. It is a serine protease inhibitor that functions by slowing down fibrinolysis, the process that leads to the breakdown of blood clots.

Etymology

The term "aprotinin" is derived from the Greek words "a-", meaning "not", and "proteino", meaning "protein". This is in reference to its function as a protease inhibitor.

Usage

Aprotinin is used in surgery to reduce bleeding and decrease the need for blood transfusion. It is particularly useful in complex cardiac surgery and liver transplantation. It is administered intravenously.

Mechanism of Action

Aprotinin works by inhibiting various serine proteases in the body, particularly those involved in the coagulation process. This includes plasmin, kallikrein, and trypsin. By inhibiting these enzymes, aprotinin slows down the process of fibrinolysis, thereby helping to prevent excessive bleeding.

Side Effects

Potential side effects of aprotinin include allergic reactions, kidney problems, and increased risk of heart attack or stroke. It is therefore important to use this medication under the supervision of a healthcare professional.

Related Terms

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