Abaloparatide
Abaloparatide
Abaloparatide (pronounced as ab-a-lo-PAR-a-tide) is a synthetic peptide analog of parathyroid hormone-related protein (PTHrP), used for the treatment of osteoporosis in postmenopausal women who are at high risk for fracture.
Etymology
The term "Abaloparatide" is derived from the combination of the prefix "aba-", which signifies "away from", and "loparatide", a derivative of "paratide", which is a short form of parathyroid hormone. The name signifies that the drug is a variant of the parathyroid hormone, but with a different structure and function.
Usage
Abaloparatide is used to treat osteoporosis in postmenopausal women who are at high risk for fracture. It works by increasing bone mass and strength, thereby reducing the risk of spine and non-spine fractures.
Mechanism of Action
Abaloparatide binds to the same receptor as the parathyroid hormone (PTH) and PTHrP, but it activates the receptor in a slightly different way. This results in an increase in bone formation and a decrease in bone resorption, which leads to an increase in bone mineral density and a decrease in the risk of fracture.
Related Terms
- Osteoporosis: A condition in which bones become weak and brittle.
- Parathyroid hormone (PTH): A hormone produced by the parathyroid glands that regulates the levels of calcium and phosphorus in the body.
- Parathyroid hormone-related protein (PTHrP): A protein that, like the parathyroid hormone, can increase the concentration of calcium in the blood.
Side Effects
Common side effects of Abaloparatide include hypercalcemia, dizziness, nausea, headache, palpitations, fatigue, upper abdominal pain, and vertigo.
External links
- Medical encyclopedia article on Abaloparatide
- Wikipedia's article - Abaloparatide
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