Arctiin

Arctiin is a natural lignan predominantly located in several plants within the Asteraceae family, notably in the greater burdock (Arctium lappa) and Centaurea imperialis. Additionally, it can be found in species such as Trachelospermum asiaticum, Saussurea heteromalla, and Forsythia viridissima. Chemically, arctiin is recognized as the glucoside derivative of arctigenin, its aglycone counterpart.

Arctiin

Chemical Structure

Arctiin's molecular structure comprises a glucose unit attached to the aglycone arctigenin, making it a specific type of glucoside. This bonding occurs at the oxygen atom, characteristic of lignans.

Sources

Arctiin is found predominantly in:

• Greater burdock (Arctium lappa): A medicinal plant often used in traditional medicine.
• Centaurea imperialis: Another member of the Asteraceae family.
• Trachelospermum asiaticum
• Saussurea heteromalla
• Forsythia viridissima

Pharmacological Properties

Anticancer Activity

Both arctiin and its aglycone form, arctigenin, have displayed potential anticancer properties in various studies. These compounds interfere with tumor progression and have shown promise in:

• Inhibiting cancer cell proliferation.
• Promoting apoptosis or programmed cell death in malignant cells.
• Disrupting metastatic pathways in specific cancer types.

Clinical Relevance

Given its anticancer properties, arctiin and arctigenin are under investigation for potential therapeutic applications in oncology. However, further research, including clinical trials, is essential to ascertain their efficacy and safety profile.

See also

• Lignans
• Phytochemicals
• Anticancer agents
• Herbal Medicine

External links

• Arctiin entry in the public domain NCI Dictionary of Cancer Terms

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