Cholecystokinin B receptor
Cholecystokinin B receptor (CCKBR) is a protein that in humans is encoded by the CCKBR gene. This receptor belongs to the G protein-coupled receptor family, specifically the subfamily of neuropeptide receptors. CCKBR is primarily found in the gastrointestinal tract and the central nervous system.
Function
The Cholecystokinin B receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system, this receptor regulates satiety and the release of beta-endorphin and dopamine.
Clinical significance
Alterations in the CCKBR gene have been associated with panic disorder, schizophrenia, and gastrointestinal disorders. In addition, CCKBR has been implicated in several types of cancer, including gastric cancer and colorectal cancer.
Pharmacology
Several drugs target the Cholecystokinin B receptor, including proglumide and lorglumide, which are used in the treatment of gastrointestinal disorders.
See also
References
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Contributors: Prab R. Tumpati, MD
