5F-CUMYL-PEGACLONE
5F-CUMYL-PEGACLONE
5F-CUMYL-PEGACLONE is a synthetic cannabinoid that has been used in scientific research and is known for its potent effects on the endocannabinoid system. It is a designer drug that has been found in some recreational drug products.
Chemical Properties
5F-CUMYL-PEGACLONE is a member of the indazole-based synthetic cannabinoids. Its chemical structure includes a fluorinated phenyl group, which is a common feature in many synthetic cannabinoids to enhance their potency and metabolic stability. The compound is known for its high affinity for the CB1 receptor and CB2 receptor, which are part of the endocannabinoid system.
Pharmacology
The pharmacological effects of 5F-CUMYL-PEGACLONE are primarily mediated through its action as a full agonist at the CB1 and CB2 receptors. This interaction leads to the modulation of neurotransmitter release in the brain, resulting in psychoactive effects similar to those of tetrahydrocannabinol (THC), the active component of cannabis.
Effects and Toxicity
The effects of 5F-CUMYL-PEGACLONE can include euphoria, altered perception, and relaxation. However, due to its potency, it can also cause adverse effects such as anxiety, paranoia, and in some cases, severe toxicity. The use of synthetic cannabinoids like 5F-CUMYL-PEGACLONE has been associated with acute health risks, including tachycardia, hypertension, and seizures.
Legal Status
The legal status of 5F-CUMYL-PEGACLONE varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of medical use. Regulatory agencies have been working to control the distribution and sale of synthetic cannabinoids to prevent public health issues.
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Contributors: Prab R. Tumpati, MD