Flurbiprofen

A nonsteroidal anti-inflammatory drug

Flurbiprofen
[[File:|frameless|220px|alt=|]]
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG

Overview

Chemical structure of Flurbiprofen

Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It is commonly prescribed for conditions such as arthritis, dental pain, and postoperative pain. Flurbiprofen works by inhibiting the production of prostaglandins, which are chemicals in the body responsible for inflammation and pain.

Pharmacology

Flurbiprofen is a member of the propionic acid class of NSAIDs, which also includes drugs like ibuprofen and naproxen. It is available in both oral and topical formulations. The drug is absorbed in the gastrointestinal tract and is metabolized in the liver. Its mechanism of action involves the inhibition of the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are involved in the synthesis of prostaglandins.

Medical Uses

Flurbiprofen is used to manage various types of pain and inflammation. It is effective in treating:

• Osteoarthritis and rheumatoid arthritis
• Ankylosing spondylitis
• Dysmenorrhea (painful menstruation)
• Migraine
• Postoperative pain

Side Effects

Common side effects of flurbiprofen include:

• Gastrointestinal discomfort
• Nausea
• Dizziness
• Headache

Serious side effects may include:

• Gastrointestinal bleeding
• Kidney damage
• Liver damage
• Allergic reactions

Contraindications

Flurbiprofen should not be used in individuals with:

• Hypersensitivity to NSAIDs
• Peptic ulcer disease
• Severe heart failure
• Severe liver impairment

Interactions

Flurbiprofen may interact with other medications, including:

• Anticoagulants such as warfarin
• Antihypertensives
• Diuretics
• Lithium

Related pages

• Nonsteroidal anti-inflammatory drug
• Ibuprofen
• Naproxen
• Cyclooxygenase