Sertoli–Leydig cell tumour: Difference between revisions
CSV import |
CSV import |
||
| Line 1: | Line 1: | ||
{{SI}} | |||
{{Infobox medical condition | |||
| name = Sertoli–Leydig cell tumour | |||
| image = [[File:Sertoli-Leydig_cell_tumour_-_very_high_mag.jpg|left|thumb|Sertoli–Leydig cell tumour under very high magnification]] | |||
| caption = Micrograph of a Sertoli–Leydig cell tumour | |||
| field = [[Oncology]], [[Gynecology]] | |||
| synonyms = Androblastoma | |||
| symptoms = [[Virilization]], [[abdominal pain]], [[pelvic mass]] | |||
| complications = [[Infertility]], [[malignancy]] | |||
| onset = Typically in [[young women]] | |||
| duration = Variable | |||
| causes = [[Genetic mutations]] | |||
| risks = [[Family history]], [[genetic syndromes]] | |||
| diagnosis = [[Histopathology]], [[imaging studies]] | |||
| differential = [[Granulosa cell tumour]], [[thecoma]], [[fibroma]] | |||
| prevention = None known | |||
| treatment = [[Surgery]], [[chemotherapy]] | |||
| medication = [[Hormonal therapy]] | |||
| prognosis = Generally good with treatment | |||
| frequency = Rare | |||
}} | |||
[[File:Leydig cell tumour3.jpg|Leydig cell tumour|thumb|left]] | |||
'''Sertoli–Leydig cell tumour''', also known as '''androblastoma''', is a rare type of [[ovarian cancer]] that involves both the [[Sertoli cells]], which are part of the [[seminiferous tubules]] in the testes, and the [[Leydig cells]], which are found in the testicular interstitium. These tumors are part of a group of neoplasms referred to as [[sex cord-stromal tumors]] of the ovary. They account for less than 0.5% of all ovarian tumors. Sertoli–Leydig cell tumors are most commonly found in young women, typically presenting in the second and third decades of life. | '''Sertoli–Leydig cell tumour''', also known as '''androblastoma''', is a rare type of [[ovarian cancer]] that involves both the [[Sertoli cells]], which are part of the [[seminiferous tubules]] in the testes, and the [[Leydig cells]], which are found in the testicular interstitium. These tumors are part of a group of neoplasms referred to as [[sex cord-stromal tumors]] of the ovary. They account for less than 0.5% of all ovarian tumors. Sertoli–Leydig cell tumors are most commonly found in young women, typically presenting in the second and third decades of life. | ||
==Symptoms and Signs== | ==Symptoms and Signs== | ||
The clinical presentation of Sertoli–Leydig cell tumors can vary significantly but often includes signs and symptoms of [[virilization]] due to the production of male sex hormones, primarily [[testosterone]]. These symptoms may include [[hirsutism]], [[amenorrhea]], a deepened voice, and [[clitoromegaly]]. Other possible symptoms include abdominal pain or a palpable mass in the abdomen, which could indicate the presence of a tumor. | The clinical presentation of Sertoli–Leydig cell tumors can vary significantly but often includes signs and symptoms of [[virilization]] due to the production of male sex hormones, primarily [[testosterone]]. These symptoms may include [[hirsutism]], [[amenorrhea]], a deepened voice, and [[clitoromegaly]]. Other possible symptoms include abdominal pain or a palpable mass in the abdomen, which could indicate the presence of a tumor. | ||
==Diagnosis== | ==Diagnosis== | ||
Diagnosis of Sertoli–Leydig cell tumors typically involves a combination of [[physical examination]], [[ultrasound]] imaging of the pelvis, and blood tests to measure hormone levels. Elevated levels of testosterone or other androgens may suggest the presence of these tumors. In some cases, a [[computed tomography (CT) scan]] or [[magnetic resonance imaging (MRI)]] may be used to further evaluate the tumor's size and spread. Definitive diagnosis is usually achieved through [[surgical resection]] and [[histopathological examination]] of the tumor tissue. | Diagnosis of Sertoli–Leydig cell tumors typically involves a combination of [[physical examination]], [[ultrasound]] imaging of the pelvis, and blood tests to measure hormone levels. Elevated levels of testosterone or other androgens may suggest the presence of these tumors. In some cases, a [[computed tomography (CT) scan]] or [[magnetic resonance imaging (MRI)]] may be used to further evaluate the tumor's size and spread. Definitive diagnosis is usually achieved through [[surgical resection]] and [[histopathological examination]] of the tumor tissue. | ||
==Treatment== | ==Treatment== | ||
The primary treatment for Sertoli–Leydig cell tumors is surgical removal of the tumor. This may involve [[oophorectomy]] (removal of one ovary) or [[bilateral salpingo-oophorectomy]] (removal of both ovaries and fallopian tubes), depending on the extent of the disease and the patient's desire to preserve fertility. In advanced cases, additional treatments such as [[chemotherapy]] or [[radiation therapy]] may be considered. The choice of treatment depends on the stage of the tumor, its histological features, and the patient's overall health and reproductive goals. | The primary treatment for Sertoli–Leydig cell tumors is surgical removal of the tumor. This may involve [[oophorectomy]] (removal of one ovary) or [[bilateral salpingo-oophorectomy]] (removal of both ovaries and fallopian tubes), depending on the extent of the disease and the patient's desire to preserve fertility. In advanced cases, additional treatments such as [[chemotherapy]] or [[radiation therapy]] may be considered. The choice of treatment depends on the stage of the tumor, its histological features, and the patient's overall health and reproductive goals. | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for patients with Sertoli–Leydig cell tumors is generally favorable, especially for those with tumors confined to the ovary and with low-grade histology. The overall 5-year survival rate is high, but recurrence can occur, necessitating long-term follow-up. | The prognosis for patients with Sertoli–Leydig cell tumors is generally favorable, especially for those with tumors confined to the ovary and with low-grade histology. The overall 5-year survival rate is high, but recurrence can occur, necessitating long-term follow-up. | ||
==Epidemiology== | ==Epidemiology== | ||
Sertoli–Leydig cell tumors are rare, accounting for less than 0.5% of all ovarian tumors. They are most commonly diagnosed in young women, with a peak incidence in the second and third decades of life. | Sertoli–Leydig cell tumors are rare, accounting for less than 0.5% of all ovarian tumors. They are most commonly diagnosed in young women, with a peak incidence in the second and third decades of life. | ||
==See Also== | ==See Also== | ||
* [[Ovarian cancer]] | * [[Ovarian cancer]] | ||
| Line 21: | Line 37: | ||
* [[Virilization]] | * [[Virilization]] | ||
* [[Oophorectomy]] | * [[Oophorectomy]] | ||
[[Category:Ovarian cancer]] | [[Category:Ovarian cancer]] | ||
[[Category:Endocrine neoplasia]] | [[Category:Endocrine neoplasia]] | ||
[[Category:Rare cancers]] | [[Category:Rare cancers]] | ||
{{Gynecology}} | {{Gynecology}} | ||
{{Oncology}} | {{Oncology}} | ||
{{Endocrinology}} | {{Endocrinology}} | ||
{{medicine-stub}} | {{medicine-stub}} | ||
Latest revision as of 00:12, 10 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Sertoli–Leydig cell tumour | |
|---|---|
 | |
| Synonyms | Androblastoma |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Virilization, abdominal pain, pelvic mass |
| Complications | Infertility, malignancy |
| Onset | Typically in young women |
| Duration | Variable |
| Types | N/A |
| Causes | Genetic mutations |
| Risks | Family history, genetic syndromes |
| Diagnosis | Histopathology, imaging studies |
| Differential diagnosis | Granulosa cell tumour, thecoma, fibroma |
| Prevention | None known |
| Treatment | Surgery, chemotherapy |
| Medication | Hormonal therapy |
| Prognosis | Generally good with treatment |
| Frequency | Rare |
| Deaths | N/A |
Sertoli–Leydig cell tumour, also known as androblastoma, is a rare type of ovarian cancer that involves both the Sertoli cells, which are part of the seminiferous tubules in the testes, and the Leydig cells, which are found in the testicular interstitium. These tumors are part of a group of neoplasms referred to as sex cord-stromal tumors of the ovary. They account for less than 0.5% of all ovarian tumors. Sertoli–Leydig cell tumors are most commonly found in young women, typically presenting in the second and third decades of life.
Symptoms and Signs[edit]
The clinical presentation of Sertoli–Leydig cell tumors can vary significantly but often includes signs and symptoms of virilization due to the production of male sex hormones, primarily testosterone. These symptoms may include hirsutism, amenorrhea, a deepened voice, and clitoromegaly. Other possible symptoms include abdominal pain or a palpable mass in the abdomen, which could indicate the presence of a tumor.
Diagnosis[edit]
Diagnosis of Sertoli–Leydig cell tumors typically involves a combination of physical examination, ultrasound imaging of the pelvis, and blood tests to measure hormone levels. Elevated levels of testosterone or other androgens may suggest the presence of these tumors. In some cases, a computed tomography (CT) scan or magnetic resonance imaging (MRI) may be used to further evaluate the tumor's size and spread. Definitive diagnosis is usually achieved through surgical resection and histopathological examination of the tumor tissue.
Treatment[edit]
The primary treatment for Sertoli–Leydig cell tumors is surgical removal of the tumor. This may involve oophorectomy (removal of one ovary) or bilateral salpingo-oophorectomy (removal of both ovaries and fallopian tubes), depending on the extent of the disease and the patient's desire to preserve fertility. In advanced cases, additional treatments such as chemotherapy or radiation therapy may be considered. The choice of treatment depends on the stage of the tumor, its histological features, and the patient's overall health and reproductive goals.
Prognosis[edit]
The prognosis for patients with Sertoli–Leydig cell tumors is generally favorable, especially for those with tumors confined to the ovary and with low-grade histology. The overall 5-year survival rate is high, but recurrence can occur, necessitating long-term follow-up.
Epidemiology[edit]
Sertoli–Leydig cell tumors are rare, accounting for less than 0.5% of all ovarian tumors. They are most commonly diagnosed in young women, with a peak incidence in the second and third decades of life.
See Also[edit]
| Gynecology and Obstetrics | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
This Gynecology related article is a stub.
|
| Oncology | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
This oncology-related article is a stub.
|
| Physiology of the endocrine system | ||||||||
|---|---|---|---|---|---|---|---|---|
|
