Leydig cell

Leydig cells, also known as interstitial cells of Leydig, are found adjacent to the seminiferous tubules in the testicle. They produce testosterone in the presence of luteinizing hormone (LH). Leydig cells are polyhedral in shape, display a large nucleus, an eosinophilic cytoplasm and numerous lipid-filled vesicles.

Function

Leydig cells generate testosterone in response to luteinizing hormone (LH). Testosterone is responsible for the primary and secondary sexual characteristics in males. It also promotes sexual drive and regulates the production of sperm.

Development

Leydig cells develop in the testes during embryogenesis. They originate from the mesenchyme of the gonadal ridge. The development of Leydig cells is influenced by several hormones, including LH and human chorionic gonadotropin (hCG).

Clinical significance

Abnormalities in Leydig cells can lead to several medical conditions. For instance, Leydig cell hypoplasia is a rare form of male pseudohermaphroditism. Leydig cell tumors, although rare, can also occur and may lead to endocrine disorders.

See also

• Sertoli cell
• Testosterone
• Luteinizing hormone

References

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