JWH-195

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JWH-195 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was developed by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-195 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its IUPAC name is (1-pentylindol-3-yl)-(2-methoxyphenyl)methanone. The compound has a molecular formula of C21H23NO2 and a molar mass of 321.41 g/mol.

The structure of JWH-195 includes a pentyl chain attached to the indole core, which is a common feature in many synthetic cannabinoids, contributing to its affinity for cannabinoid receptors. The methoxyphenyl group is attached to the indole via a ketone linkage, which is crucial for its activity.

Pharmacology

JWH-195 acts as a full agonist at both the CB1 and CB2 cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-195 for the CB1 receptor is high, which suggests that it can produce effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, as a synthetic cannabinoid, JWH-195 may have a different safety profile and potency compared to natural cannabinoids.

Legal Status

The legal status of JWH-195 varies by country. In many jurisdictions, synthetic cannabinoids like JWH-195 are controlled substances due to their potential for abuse and lack of medical use. Researchers must comply with local regulations when studying these compounds.

Research and Applications

JWH-195, like other synthetic cannabinoids, is primarily used in scientific research to study the endocannabinoid system and to develop new therapeutic agents. Its role in research is to help understand the interactions between synthetic cannabinoids and cannabinoid receptors, which can inform the development of new drugs for conditions such as chronic pain, anxiety, and neurodegenerative diseases.

Safety and Toxicology

The safety profile of JWH-195 is not well-documented, as it is primarily used in research settings. Synthetic cannabinoids have been associated with adverse effects such as tachycardia, agitation, and hallucinations. Therefore, caution is advised when handling these compounds in a laboratory setting.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Endocannabinoid system
• Tetrahydrocannabinol