TAS2R13

TAS2R13

TAS2R13 is a protein that in humans is encoded by the TAS2R13 gene. It is a member of the TAS2R gene family, which is responsible for the bitter taste perception. The TAS2R13 protein is a G protein-coupled receptor located in the taste buds of the tongue and plays a crucial role in the detection of bitter compounds.

Function

The TAS2R13 protein is a part of the taste receptor, type 2, family. These receptors are expressed in the taste receptor cells of the tongue and palate epithelium and are organized in the taste buds in tight clusters. The TAS2R13 protein, like other members of this family, is a G protein-coupled receptor. This means it activates a G protein inside the cell when a bitter compound binds to the receptor on the outside of the cell. This activation leads to a series of reactions that ultimately result in the perception of a bitter taste.

Clinical significance

Variations in the TAS2R13 gene have been associated with differences in the perception of bitter taste. Some individuals may be more sensitive to certain bitter compounds due to variations in this gene. This can influence dietary choices and could potentially have implications for health and nutrition.

See also

• Taste receptor
• G protein-coupled receptor
• TAS2R gene family

References

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