CUMYL-BICA

CUMYL-BICA is a synthetic cannabinoid that has been identified in various recreational drug products. It is a potent agonist of the cannabinoid receptors, specifically targeting the CB1 receptor, which is primarily responsible for the psychoactive effects of cannabinoids.

Chemical Structure and Properties

CUMYL-BICA belongs to the indazole-3-carboxamide family of synthetic cannabinoids. Its chemical structure is characterized by a 1-(4-cyanobutyl) group attached to an indazole core, with an N-(2-phenylpropan-2-yl) carboxamide moiety. This structure is similar to other synthetic cannabinoids, which often feature a core indazole or indole structure with various substituents that modulate their activity at cannabinoid receptors.

The compound is typically found as a white powder and is soluble in organic solvents. It has a melting point of 85-87 °C and a boiling point of approximately 450 °C.

Pharmacology

CUMYL-BICA acts as a full agonist at the CB1 receptor, which is part of the endocannabinoid system. This system plays a crucial role in regulating various physiological processes, including mood, appetite, and pain sensation. The activation of CB1 receptors by CUMYL-BICA leads to psychoactive effects similar to those produced by tetrahydrocannabinol (THC), the primary active component of cannabis.

Legal Status

Due to its potential for abuse and lack of medical use, CUMYL-BICA is classified as a controlled substance in many jurisdictions. It is often included in legislation targeting synthetic cannabinoids, which are frequently sold as "legal highs" or "herbal incense."

Health Effects and Risks

The use of CUMYL-BICA, like other synthetic cannabinoids, is associated with a range of adverse health effects. These can include anxiety, paranoia, tachycardia, hypertension, and in severe cases, psychosis or seizures. The variability in potency and the presence of unknown impurities in street products further increase the risk of adverse effects.

Detection and Analysis

CUMYL-BICA can be detected in biological samples using advanced analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS). These methods allow for the identification and quantification of the compound in various matrices, including blood, urine, and seized drug samples.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• Endocannabinoid system
• Tetrahydrocannabinol