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{{PAGENAME}} - a methylated derivative of l-arginine that is a competitive inhibitor of nitric oxide synthase (nos). Asymmetric dimethylarginine (adma) is formed when s-adenosylmethionine protein n-methyltransferases transfer methyl groups from s-adenosylmethionine to arginine. Free adma in plasma competes with the l-arginine for binding to the heme in nos and inhibits nitric oxide (no) synthesis. Decreased synthesis of no inhibits vasodilation and leads to endothelial dysfunction. Elevated plasma levels of adma are seen in certain types of cancer, cardiovascular disease, hypertension, hyperlipidemia, type 2 diabetes mellitus, and increased oxidative stress.
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'''Adma''' is a medical condition characterized by specific physiological and biochemical abnormalities. It is primarily studied within the field of [[cardiology]] due to its impact on cardiovascular health.
 
==Pathophysiology==
Adma, or Asymmetric Dimethylarginine, is a naturally occurring chemical found in blood plasma. It is a derivative of the amino acid [[arginine]] and is produced as a result of protein modification processes. Adma is known to inhibit the production of [[nitric oxide]] (NO), a critical molecule involved in vascular homeostasis. NO is synthesized by [[endothelial cells]] and plays a vital role in maintaining [[vascular tone]], [[blood pressure]], and [[endothelial function]].
 
The accumulation of Adma in the bloodstream can lead to endothelial dysfunction, which is a precursor to atherosclerosis and other cardiovascular diseases. Elevated levels of Adma are associated with increased risk of [[hypertension]], [[coronary artery disease]], and [[chronic kidney disease]].
 
==Causes==
The primary cause of elevated Adma levels is impaired degradation by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Factors that can lead to increased Adma levels include:
* [[Genetic predisposition]]
* [[Chronic kidney disease]]
* [[Diabetes mellitus]]
* [[Hypercholesterolemia]]
* [[Smoking]]
* [[Inflammation]]
 
==Clinical Significance==
Adma is considered a biomarker for cardiovascular risk. Elevated levels of Adma have been linked to:
* [[Endothelial dysfunction]]
* [[Atherosclerosis]]
* [[Heart failure]]
* [[Stroke]]
 
==Diagnosis==
The diagnosis of elevated Adma levels is typically made through blood tests that measure its concentration in plasma. These tests are often used in conjunction with other assessments of cardiovascular risk.
 
==Treatment==
There is currently no specific treatment for reducing Adma levels directly. However, managing underlying conditions and risk factors can help mitigate its effects. Treatment strategies may include:
* [[Lifestyle modifications]] such as diet and exercise
* [[Antihypertensive medications]]
* [[Lipid-lowering agents]]
* [[Antidiabetic drugs]]
 
==Research==
Ongoing research is focused on understanding the role of Adma in cardiovascular disease and exploring potential therapeutic interventions. Studies are investigating the impact of various drugs on Adma levels and their potential to improve endothelial function.
 
==See also==
* [[Nitric oxide synthase]]
* [[Endothelial dysfunction]]
* [[Cardiovascular disease]]
 
==External links==
* [Link to relevant medical resources]
 
{{Cardiology}}
[[Category:Cardiology]]
[[Category:Biomarkers]]
[[Category:Vascular diseases]]

Latest revision as of 16:58, 1 January 2025


Adma
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Adma is a medical condition characterized by specific physiological and biochemical abnormalities. It is primarily studied within the field of cardiology due to its impact on cardiovascular health.

Pathophysiology[edit]

Adma, or Asymmetric Dimethylarginine, is a naturally occurring chemical found in blood plasma. It is a derivative of the amino acid arginine and is produced as a result of protein modification processes. Adma is known to inhibit the production of nitric oxide (NO), a critical molecule involved in vascular homeostasis. NO is synthesized by endothelial cells and plays a vital role in maintaining vascular tone, blood pressure, and endothelial function.

The accumulation of Adma in the bloodstream can lead to endothelial dysfunction, which is a precursor to atherosclerosis and other cardiovascular diseases. Elevated levels of Adma are associated with increased risk of hypertension, coronary artery disease, and chronic kidney disease.

Causes[edit]

The primary cause of elevated Adma levels is impaired degradation by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Factors that can lead to increased Adma levels include:

Clinical Significance[edit]

Adma is considered a biomarker for cardiovascular risk. Elevated levels of Adma have been linked to:

Diagnosis[edit]

The diagnosis of elevated Adma levels is typically made through blood tests that measure its concentration in plasma. These tests are often used in conjunction with other assessments of cardiovascular risk.

Treatment[edit]

There is currently no specific treatment for reducing Adma levels directly. However, managing underlying conditions and risk factors can help mitigate its effects. Treatment strategies may include:

Research[edit]

Ongoing research is focused on understanding the role of Adma in cardiovascular disease and exploring potential therapeutic interventions. Studies are investigating the impact of various drugs on Adma levels and their potential to improve endothelial function.

See also[edit]

External links[edit]

  • [Link to relevant medical resources]



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