Enprostil: Difference between revisions
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{{Short description|A synthetic prostaglandin analog used in medicine}} | |||
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'''Enprostil''' is a [[synthetic]] [[prostaglandin]] [[analog]] used in the treatment of [[gastrointestinal]] disorders. It is primarily utilized for its [[cytoprotective]] properties in the [[gastric mucosa]]. | |||
Enprostil | ==Pharmacology== | ||
Enprostil is a [[prostaglandin E2]] analog, which means it mimics the action of naturally occurring prostaglandins in the body. Prostaglandins are [[lipid compounds]] that have diverse hormone-like effects, including the regulation of [[inflammation]], [[gastric acid secretion]], and [[mucosal protection]]. | |||
== | ===Mechanism of Action=== | ||
Enprostil works by binding to specific [[prostaglandin receptors]] in the [[stomach lining]], leading to increased production of [[mucus]] and [[bicarbonate]], which help protect the stomach lining from [[acidic]] damage. It also inhibits the secretion of [[gastric acid]], thereby reducing the risk of [[ulceration]]. | |||
Enprostil is used | ==Medical Uses== | ||
Enprostil is used in the management of [[peptic ulcer disease]] and [[gastritis]]. It is particularly beneficial in patients who require [[nonsteroidal anti-inflammatory drugs]] (NSAIDs), as these medications can increase the risk of [[gastric ulcers]]. | |||
== Side Effects == | ==Side Effects== | ||
Common side effects of enprostil include [[diarrhea]], [[abdominal pain]], and [[nausea]]. These effects are generally mild and resolve with continued use. However, enprostil should be used with caution in patients with [[inflammatory bowel disease]] due to its potential to exacerbate symptoms. | |||
==Contraindications== | |||
Enprostil is contraindicated in [[pregnancy]] due to its potential to induce [[uterine contractions]] and cause [[miscarriage]]. It should also be avoided in patients with known [[hypersensitivity]] to prostaglandins. | |||
== Contraindications == | |||
Enprostil | |||
==Related pages== | |||
* [[Prostaglandin]] | * [[Prostaglandin]] | ||
* [[Gastric | * [[Peptic ulcer disease]] | ||
* [[Gastric acid]] | |||
* [[Nonsteroidal anti-inflammatory drug]] | * [[Nonsteroidal anti-inflammatory drug]] | ||
[[Category:Prostaglandins]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 03:46, 13 February 2025
A synthetic prostaglandin analog used in medicine
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Enprostil is a synthetic prostaglandin analog used in the treatment of gastrointestinal disorders. It is primarily utilized for its cytoprotective properties in the gastric mucosa.
Pharmacology
Enprostil is a prostaglandin E2 analog, which means it mimics the action of naturally occurring prostaglandins in the body. Prostaglandins are lipid compounds that have diverse hormone-like effects, including the regulation of inflammation, gastric acid secretion, and mucosal protection.
Mechanism of Action
Enprostil works by binding to specific prostaglandin receptors in the stomach lining, leading to increased production of mucus and bicarbonate, which help protect the stomach lining from acidic damage. It also inhibits the secretion of gastric acid, thereby reducing the risk of ulceration.
Medical Uses
Enprostil is used in the management of peptic ulcer disease and gastritis. It is particularly beneficial in patients who require nonsteroidal anti-inflammatory drugs (NSAIDs), as these medications can increase the risk of gastric ulcers.
Side Effects
Common side effects of enprostil include diarrhea, abdominal pain, and nausea. These effects are generally mild and resolve with continued use. However, enprostil should be used with caution in patients with inflammatory bowel disease due to its potential to exacerbate symptoms.
Contraindications
Enprostil is contraindicated in pregnancy due to its potential to induce uterine contractions and cause miscarriage. It should also be avoided in patients with known hypersensitivity to prostaglandins.
