Weber Christian disease
Weber Christian Disease
Weber Christian Disease (pronounced: WEB-er KRIS-tian dih-ZEEZ), also known as Relapsing Febrile Nodular Nonsuppurative Panniculitis, is a rare inflammatory disease that affects the fatty tissue layer under the skin, known as the subcutaneous fat.
Etymology
The disease is named after the American dermatologists Frederick Parkes Weber and Henry Asbury Christian, who first described the condition in the early 20th century.
Definition
Weber Christian Disease is characterized by recurrent episodes of fever accompanied by the formation of nodules in the fatty layer of the skin. These nodules can vary in size and are often tender and erythematous. They typically resolve spontaneously but can leave behind areas of lipoatrophy or lipodystrophy, which are conditions characterized by the loss of fat tissue.
Symptoms
The most common symptoms of Weber Christian Disease include:
- Recurrent fever
- Tender skin nodules
- Fatigue
- Weight loss
- Malaise
Less common symptoms can include:
- Joint pain (arthralgia)
- Abdominal pain
- Nausea and vomiting
Diagnosis
Diagnosis of Weber Christian Disease is typically made based on the clinical presentation and histopathological examination of a skin biopsy. The biopsy will show lobular panniculitis with a mixed inflammatory infiltrate.
Treatment
Treatment for Weber Christian Disease is primarily symptomatic and can include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and other immunosuppressive agents. In severe cases, surgical removal of the nodules may be necessary.
Prognosis
The prognosis for individuals with Weber Christian Disease is generally good, although the disease can be chronic and relapsing. Most individuals experience a significant improvement in symptoms with treatment.
See Also
External links
- Medical encyclopedia article on Weber Christian disease
- Wikipedia's article - Weber Christian disease
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