JWH-194

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JWH-194 is a synthetic cannabinoid from the naphthoylindole family, which acts as a potent agonist of the cannabinoid receptors. It was first synthesized by John W. Huffman and his team at Clemson University as part of research into the structure-activity relationships of cannabinoids.

Chemical Structure and Properties

JWH-194 is chemically classified as a naphthoylindole, which is a subclass of synthetic cannabinoids. Its chemical structure consists of a 1-pentyl-3-(4-methoxy-1-naphthoyl)indole core. The presence of the methoxy group on the naphthalene ring is a distinguishing feature of this compound.

The molecular formula of JWH-194 is C₂₅H₂₅NO₂, and it has a molar mass of 371.47 g/mol. The compound is typically synthesized in a laboratory setting and is not found naturally.

Pharmacology

JWH-194 acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a role in regulating various physiological processes including pain sensation, mood, and appetite.

The binding affinity of JWH-194 for the CB₁ receptor is high, which suggests that it can produce effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, the specific effects and potency of JWH-194 in humans have not been extensively studied.

Legal Status

The legal status of JWH-194 varies by country. In many jurisdictions, synthetic cannabinoids like JWH-194 are classified as controlled substances due to their potential for abuse and lack of medical use. Researchers must obtain special licenses to study these compounds.

Safety and Toxicology

The safety profile of JWH-194 is not well-documented, as it is primarily used in research settings. Synthetic cannabinoids have been associated with a range of adverse effects, including tachycardia, hypertension, hallucinations, and psychosis.

Research Applications

JWH-194 is used in scientific research to study the endocannabinoid system and to develop new therapeutic agents that target cannabinoid receptors. It serves as a tool for understanding the pharmacological effects of cannabinoids and for exploring potential medical applications.

Also see

• Synthetic cannabinoids
• Cannabinoid receptor
• John W. Huffman
• Naphthoylindole
• Endocannabinoid system