Aggressive NK-cell leukemia: Difference between revisions
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{{Infobox medical condition | {{Infobox medical condition | ||
| name = Aggressive NK-cell leukemia | | name = Aggressive NK-cell leukemia | ||
| image =[[File: | | image =[[File:Natural_killer_cell.png|thumb|Natural killer cell]] | ||
| caption = Natural killer cell | | caption = Natural killer cell | ||
| field = [[Hematology]] | | field = [[Hematology]] | ||
| Line 71: | Line 71: | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Viral oncology]] | [[Category:Viral oncology]] | ||
Latest revision as of 22:29, 26 April 2025
| Aggressive NK-cell leukemia | |
|---|---|
 | |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fever, weight loss, night sweats, hepatosplenomegaly, lymphadenopathy |
| Complications | Hemophagocytic lymphohistiocytosis, multi-organ failure |
| Onset | Typically in young adults |
| Duration | Acute |
| Types | N/A |
| Causes | Genetic mutations, Epstein-Barr virus |
| Risks | Immunosuppression, Asian descent |
| Diagnosis | Blood test, bone marrow biopsy, immunophenotyping |
| Differential diagnosis | T-cell leukemia, B-cell lymphoma, infectious mononucleosis |
| Prevention | N/A |
| Treatment | Chemotherapy, hematopoietic stem cell transplantation |
| Medication | N/A |
| Prognosis | Poor |
| Frequency | Rare |
| Deaths | N/A |
| Aggressive NK-cell leukemia | |
|---|---|
| ICD-10 | |
| ICD-9 | |
| DiseasesDB | |
| MedlinePlus | |
| eMedicine | |
| MeSH ID | |
Aggressive NK-cell leukemia is a rare and rapidly progressing form of leukemia characterized by the proliferation of natural killer cells. It is considered a subtype of large granular lymphocyte leukemia.
Signs and Symptoms[edit]
Patients with aggressive NK-cell leukemia often present with systemic symptoms such as fever, weight loss, night sweats, and fatigue. Other symptoms may include hepatosplenomegaly and lymphadenopathy.
Complications[edit]
This condition can lead to severe complications, including hemophagocytic lymphohistiocytosis (HLH), a life-threatening condition characterized by excessive immune activation and organ failure.
Causes[edit]
The exact cause of aggressive NK-cell leukemia is not well understood, but it is often associated with genetic mutations and viral infections, particularly the Epstein-Barr virus (EBV).
Diagnosis[edit]
Diagnosis typically involves a combination of blood tests, bone marrow biopsy, and immunophenotyping to identify the abnormal NK cells. Cytogenetic analysis may also be performed to detect specific genetic abnormalities.
Treatment[edit]
Treatment options are limited and often include chemotherapy and stem cell transplant. The prognosis for aggressive NK-cell leukemia is generally poor, with a high rate of relapse and resistance to treatment.
Epidemiology[edit]
Aggressive NK-cell leukemia is a rare disease, with a higher prevalence in East Asia. It affects both children and adults, with a slight male predominance.
See Also[edit]
References[edit]
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External Links[edit]
