T-cell prolymphocytic leukemia

T-cell prolymphocytic leukemia (TPCL) is a rare and aggressive type of leukemia that affects the T cells of the immune system.

Pronunciation

T-cell prolymphocytic leukemia is pronounced as "tee-sell proh-lim-foh-sy-tik loo-kee-mee-uh".

Etymology

The term "T-cell prolymphocytic leukemia" is derived from the type of cell it affects (T cells), the appearance of the cells (prolymphocytic, meaning they resemble immature lymphocytes), and the disease type (leukemia, a type of cancer affecting the blood and bone marrow).

Definition

T-cell prolymphocytic leukemia is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin. It is characterized by the out of control growth and multiplication of the T cells, which are a type of white blood cell responsible for fighting infections.

Symptoms

Common symptoms of T-cell prolymphocytic leukemia include fatigue, swollen lymph nodes, and an enlarged spleen (splenomegaly). Other symptoms may include skin rashes, night sweats, and unexplained weight loss.

Diagnosis

Diagnosis of T-cell prolymphocytic leukemia typically involves blood tests, bone marrow tests, and imaging tests. The disease is often found when it is advanced, as early stages may not cause noticeable symptoms.

Treatment

Treatment options for T-cell prolymphocytic leukemia may include chemotherapy, targeted therapy, and stem cell transplant. The choice of treatment depends on the patient's overall health, the stage of the disease, and the patient's personal preferences.

Related Terms

• Leukemia
• T cells
• Immune system
• Splenomegaly
• Chemotherapy
• Targeted therapy
• Stem cell transplant

External links

• Medical encyclopedia article on T-cell prolymphocytic leukemia
• Wikipedia's article - T-cell prolymphocytic leukemia

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