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Template:Tumor suppressor genes and oncogenes

From WikiMD's Wellness Encyclopedia

Tumor suppressor genes and Oncogenes
Ligand
Growth factors
ONCO
* c-Sis/PDGF
  • HGF
Receptor
Wnt signaling pathway
TSP
* CDH1
Hedgehog signaling pathway
TSP
* PTCH1
TGF beta signaling pathway
TSP
* TGF beta receptor 2
Receptor tyrosine kinase
ONCO
* ErbB/c-ErbB
    • HER2/neu
    • Her 3
  • c-Met
  • c-Ret
JAK-STAT signaling pathway
ONCO
* c-Kit
  • Flt3
Intracellular signaling P+Ps
Wnt signaling pathway
ONCO
* Beta-catenin
TSP
* APC
TGF beta signaling pathway
TSP
* SMAD2
  • SMAD4
Akt/PKB signaling pathway
ONCO
* c-Akt
TSP
* PTEN
Hippo signaling pathway
TSP
* Neurofibromin 2/Merlin
MAPK/ERK pathway
ONCO
* c-Ras
  • HRAS
  • c-Raf
TSP
* Neurofibromin 1
Nucleus
Cell cycle
ONCO
* CDK4
  • Cyclin D
  • Cyclin E
TSP
* p53
  • pRb
  • WT1
  • p16/p14arf
DNA repair/Fanconi
TSP
* BRCA1
  • BRCA2
Ubiquitin ligase
ONCO
* CBL
  • MDM2
TSP
* VHL
Transcription factor
ONCO
* AP-1
    • c-Fos
    • c-Jun
  • c-Myc
TSP
* KLF6
Mitochondrion
Apoptosis inhibitor
* SDHB
  • SDHD
Retrieved from "https://wikimd.com/index.php?title=Template:Tumor_suppressor_genes_and_oncogenes&oldid=5675053"
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