P14arf
P14arf
P14arf (pronounced "pee fourteen arf"), also known as ARF or CDKN2A, is a tumor suppressor protein that in humans is encoded by the CDKN2A gene. It is a crucial player in the cell cycle regulation and apoptosis.
Etymology
The name P14arf is derived from its molecular weight (14 kDa) and its function as an Alternative Reading Frame protein. The CDKN2A gene name stands for 'Cyclin-Dependent Kinase Inhibitor 2A'.
Function
P14arf is a tumor suppressor that controls cell proliferation by regulating the cell cycle. It does this by interacting with MDM2, a protein that normally inhibits p53, another tumor suppressor. When P14arf is present, it binds to MDM2 and prevents it from degrading p53, allowing p53 to accumulate and inhibit the cell cycle.
Clinical significance
Mutations in the CDKN2A gene that result in a non-functional P14arf protein are associated with a variety of cancers, including melanoma, pancreatic cancer, and lung cancer. As such, P14arf is a potential target for cancer therapy.
Related terms
- Tumor suppressor
- Protein
- Gene
- Cell cycle
- Apoptosis
- Alternative Reading Frame
- MDM2
- p53
- Cancer therapy
- Melanoma
- Pancreatic cancer
- Lung cancer
External links
- Medical encyclopedia article on P14arf
- Wikipedia's article - P14arf
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