Pseudoangiomatous stromal hyperplasia

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Pseudoangiomatous stromal hyperplasia
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Pseudoangiomatous stromal hyperplasia (PASH), is an overgrowth of myofibroblastic cells in the breast. It has an appearance similar to fibroadenomatoid changes.[1]

The diagnostic significance is currently uncertain, but it appears to be benign. There have been cases of PASH diagnosed where the tumors co-exist with breast cancer. Other cases have made screening for breast cancer difficult and in some cases impossible due to the number and density of the existing PASH tumors. These cases have resulted in the necessity of a mastectomy and double mastectomy.

Diagnosis

Intermediate magnification micrograph showing the relative abundance of stroma in a case of PASH. H&E stain.

The diagnosis of PASH is by biopsy.

The important differential diagnosis is angiosarcoma, from which it was first differentiated in 1986.[2]

Differential diagnosis

Treatment

The management of PASH is controversial. Excision may be indicated in enlarging masses or lesions with atypical features.

References

  1. ↑ , Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation, Am. J. Surg. Pathol., Vol. 19(Issue: 3), pp. 270–7, DOI: 10.1097/00000478-199503000-00004, PMID: 7872425,
  2. ↑ , Pseudoangiomatous hyperplasia of mammary stroma, Hum. Pathol., Vol. 17(Issue: 2), pp. 185–91, DOI: 10.1016/S0046-8177(86)80292-1, PMID: 3949338,
  3. ↑ , Pseudoangiomatous hyperplasia of mammary stroma in an HIV patient, Gen Diagn Pathol, Vol. 143(Issue: 4), pp. 251–4, PMID: 9489960,


External links


Breast disease
Inflammation
Physiological changes
and conditions
Nipple
Masses
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Contributors: Prab R. Tumpati, MD