Lymphoplasmacytic lymphoma
Lymphoplasmacytic Lymphoma
Lymphoplasmacytic lymphoma (pronounced lim-fo-plaz-ma-si-tik lim-fo-ma) is a rare type of non-Hodgkin lymphoma characterized by the presence of a specific type of cell known as a lymphoplasmacytic cell in the lymph nodes and bone marrow.
Etymology
The term "lymphoplasmacytic" is derived from the words "lymphocyte" and "plasmacyte", which are types of white blood cells. "Lymphoma" is derived from the Greek words "lympho" and "oma", meaning "lymph" and "tumor" respectively.
Definition
Lymphoplasmacytic lymphoma is a slow-growing, indolent type of non-Hodgkin lymphoma. It primarily affects the lymph nodes, bone marrow, and sometimes other organs such as the spleen and liver. The disease is characterized by the overproduction of immunoglobulin M (IgM), a type of antibody, which can lead to a condition known as Waldenström's macroglobulinemia.
Symptoms
Symptoms of lymphoplasmacytic lymphoma can vary, but may include fatigue, weight loss, night sweats, and enlarged lymph nodes. In cases where the disease has led to Waldenström's macroglobulinemia, additional symptoms such as anemia, bleeding, and neuropathy may occur.
Diagnosis
Diagnosis of lymphoplasmacytic lymphoma typically involves a combination of physical examination, blood tests, imaging studies, and biopsy of affected tissue. The presence of IgM in the blood and lymphoplasmacytic cells in the lymph nodes or bone marrow are key indicators of the disease.
Treatment
Treatment for lymphoplasmacytic lymphoma may include chemotherapy, immunotherapy, radiation therapy, and in some cases, stem cell transplant. The choice of treatment depends on the patient's overall health, the stage of the disease, and the presence of symptoms.
Related Terms
- Non-Hodgkin lymphoma
- Waldenström's macroglobulinemia
- Immunoglobulin M
- Chemotherapy
- Immunotherapy
- Radiation therapy
- Stem cell transplant
External links
- Medical encyclopedia article on Lymphoplasmacytic lymphoma
- Wikipedia's article - Lymphoplasmacytic lymphoma
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