MYD88

MYD88 is a human gene that encodes for the protein Myeloid differentiation primary response 88. This protein plays a crucial role in the immune response to foreign pathogens. It is involved in the transduction of signals from the receptors of innate immunity and is necessary for the downstream activation of NF-κB and MAPK.

Function

The MYD88 gene is a universal adapter protein used by almost all Toll-like receptors (TLRs) and Interleukin-1 receptors (IL-1Rs) to activate the NF-κB pathway. This pathway is crucial for the production of pro-inflammatory cytokines and chemokines, which are necessary for the innate immune response.

Clinical significance

Mutations in the MYD88 gene have been associated with several diseases, including Waldenström's macroglobulinemia, a type of non-Hodgkin lymphoma, and Pyogenic bacterial infections, recurrent isolated, 2. In addition, MYD88 mutations have been found in patients with Immunodeficiency 47.

See also

• Toll-like receptor
• Interleukin-1 receptor
• NF-κB
• MAPK

References

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