JWH-200

JWH-200.svg

JWH-200
JWH-200.svg
INN
Drug class
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Bioavailability
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Legal status
CAS Number
PubChem	44337698
DrugBank
ChemSpider	21106265
KEGG

JWH-200 is a synthetic cannabinoid from the naphthoylindole family. It acts as a potent agonist of the CB1 receptor and CB2 receptor, with a slight selectivity for the CB1 subtype. JWH-200 was discovered by John W. Huffman and his team at Clemson University as part of their research into the structure-activity relationships of cannabinoids.

Chemical Structure

JWH-200 has the chemical formula C₂₄H₂₄N₂O₂. Its structure includes a naphthoyl group attached to an indole core, with a morpholine ring linked via an ethyl chain. This structure is similar to other synthetic cannabinoids in the JWH series, such as JWH-018 and JWH-073.

Pharmacology

JWH-200 functions as a full agonist at both the CB1 and CB2 receptors. It has a higher affinity for the CB1 receptor, which is primarily found in the central nervous system. This receptor interaction is responsible for the psychoactive effects of JWH-200, which mimic those of tetrahydrocannabinol (THC), the active component of cannabis.

Legal Status

JWH-200 is classified as a Schedule I controlled substance in the United States, indicating that it is considered to have a high potential for abuse and no accepted medical use. In the United Kingdom, it is classified as a Class B drug. Various other countries have also regulated JWH-200 under their respective controlled substances laws.

Research and Applications

JWH-200, like other synthetic cannabinoids, has been used in scientific research to study the endocannabinoid system and to develop potential therapeutic agents. However, due to its legal status and potential for abuse, its use is highly restricted.

See Also

• Synthetic cannabinoids
• JWH-018
• JWH-073
• CB1 receptor
• CB2 receptor
• John W. Huffman