Granulomatous
Granulomatous
Granulomatous (pronunciation: gran-yuh-LOH-muh-tuhs) is a term used in medicine to describe a type of inflammation that is characterized by the formation of granulomas.
Etymology
The term "granulomatous" is derived from the Latin word "granulum," which means "small grain." It is used to describe the grain-like appearance of the inflammatory cells that form a granuloma.
Definition
A granuloma is a small area of inflammation in tissue. Granulomas are often associated with a variety of diseases, including tuberculosis, sarcoidosis, and Crohn's disease. They are typically composed of a central area of macrophages, including multi-nucleated giant cells, surrounded by a collar of lymphocytes and fibroblasts.
Related Terms
- Granuloma: A granuloma is a small area of inflammation, caused by an injury, such as from an infection, that has grouped together and often encapsulated.
- Inflammation: Inflammation is a process by which the body's white blood cells and substances they produce protect us from infection with foreign organisms, such as bacteria and viruses.
- Macrophages: Macrophages are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, and cancer cells in a process called phagocytosis.
- Lymphocytes: Lymphocytes are one of the subtypes of white blood cell in a vertebrate's immune system. They include natural killer cells (NK cells) (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity).
- Fibroblasts: Fibroblasts are a type of biological cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.
External links
- Medical encyclopedia article on Granulomatous
- Wikipedia's article - Granulomatous
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