Cycloartenol

Cycloartenol is a molecular compound that is classified as a triterpene. It is a key precursor in the biosynthesis of sterols, which are vital components of cell membranes. Cycloartenol is synthesized in plants and is the first solid evidence of the cyclization of squalene in higher plants.

Structure and Properties

Cycloartenol has a complex structure with four rings and a side chain. It is a white, crystalline solid at room temperature. Its molecular formula is C30H50O and its molecular weight is 426.72 g/mol. The compound is insoluble in water but soluble in organic solvents such as ethanol and chloroform.

Biosynthesis

The biosynthesis of cycloartenol begins with the conversion of acetyl-CoA to mevalonic acid via the mevalonate pathway. Mevalonic acid is then converted to isopentenyl pyrophosphate (IPP), which is further converted to farnesyl pyrophosphate (FPP). Two molecules of FPP are then joined to form squalene. Squalene is then converted to cycloartenol via the enzyme squalene cyclase.

Role in Sterol Synthesis

Cycloartenol is a precursor to all plant sterols, including sitosterol, stigmasterol, and campesterol. These sterols are essential components of plant cell membranes and play a key role in maintaining membrane integrity and fluidity. They also serve as precursors for the synthesis of other important biomolecules, such as vitamin D and hormones.

Biological Significance

The presence of cycloartenol in plants is a key indicator of the presence of the mevalonate pathway, which is essential for the production of many important biomolecules. The ability to synthesize cycloartenol is therefore a key characteristic of higher plants.

See Also

• Squalene
• Sterols
• Biosynthesis
• Mevalonate pathway

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  Cycloartenol molecule ball