Alprazolam triazolobenzophenone

Alprazolam triazolobenzophenone

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  Structure of Alprazolam-benzophenone

Alprazolam Triazolobenzophenone

Alprazolam triazolobenzophenone is a chemical compound that is a derivative of alprazolam, a medication commonly used to treat anxiety and panic disorders. Alprazolam belongs to the benzodiazepine class of drugs, which act on the central nervous system to produce a calming effect.

Chemical Structure

Alprazolam triazolobenzophenone is characterized by its triazolobenzodiazepine structure. The compound contains a triazole ring fused to a benzodiazepine core, which is a hallmark of its pharmacological activity. The presence of the triazole ring distinguishes it from other benzodiazepines, contributing to its unique properties.

Pharmacology

Alprazolam triazolobenzophenone acts as a GABA_A receptor agonist. By enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, it increases inhibitory neurotransmission in the brain, leading to its anxiolytic and sedative effects. This mechanism is similar to that of other benzodiazepines, but the specific structure of alprazolam triazolobenzophenone may influence its potency and duration of action.

Clinical Use

While alprazolam triazolobenzophenone itself is not used clinically, its parent compound, alprazolam, is widely prescribed for the management of anxiety disorders, including generalized anxiety disorder and panic disorder. Alprazolam is known for its rapid onset of action and effectiveness in acute anxiety relief.

Metabolism

Alprazolam is metabolized in the liver primarily by the cytochrome P450 enzyme CYP3A4. The metabolism of alprazolam triazolobenzophenone would likely follow a similar pathway, involving hydroxylation and subsequent conjugation to form inactive metabolites that are excreted in the urine.

Side Effects

The side effects of alprazolam triazolobenzophenone would be expected to mirror those of alprazolam, including drowsiness, dizziness, fatigue, and impaired coordination. Long-term use can lead to tolerance, dependence, and withdrawal symptoms upon cessation.

Related Pages

• Alprazolam
• Benzodiazepine
• GABA_A receptor
• Anxiety disorder
• Panic disorder

Benzodiazipines

• Alprazolam
• Chlordiazepoxide
• Diazepam (Oral)
• Estazolam
• Flurazepam
• Lorazepam
• Midazolam
• Oxazepam
• Quazepam
• Temazepam
• Triazolam

Anticonvulsants Drugs

• Clobazam
• Clonazepam
• Clorazepate
• Diazepam (Intravenous)

Anticonvulsants, and Benzodiazepines]