GABA A receptor
GABA A receptor (GABAA receptor, pronounced as /ˈɡæbə eɪ rɪˈsɛptər/) is a type of GABA receptor that is activated by the neurotransmitter Gamma-Aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.
Etymology
The term "GABA A receptor" is derived from the neurotransmitter that binds to it, Gamma-Aminobutyric acid (GABA), and the 'A' denotes that it is subtype A of the GABA receptors.
Structure
The GABA A receptor is a multisubunit chloride channel that is activated by GABA. It is a member of the Cys-loop receptors family of ligand-gated ion channels, which also includes the nicotinic acetylcholine receptor, the 5-HT3 receptor, and the glycine receptor.
Function
The GABA A receptor is an inhibitory channel which, when activated, decreases neuronal excitability. This function is essential for the overall balance in neuronal excitability.
Related Terms
See Also
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