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Template
:
Nitric oxide signaling modulators
From WikiMD's Medical Encyclopedia
Revision as of 19:52, 8 March 2025 by
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Nitric oxide
signaling
modulators
Forms
*
Nitroxyl anion (NO
−
; oxonitrate(1-), hyponitrite anion)
Nitric oxide (NO
⋅
; nitrogen monoxide)
Nitrosonium (NO
+
; nitrosyl cation)
Targets
sGC
*
Activators/stimulators:
Ataciguat
BAY 41-2272
BAY 41-8543
BAY 60-4552
BI-703704
Cinaciguat (BAY 58-2667)
GSK-2181236A
Praliciguat
Riociguat (BAY 63-2521)
Vericiguat
Inhibitors:
ODQ
NO donors
(
prodrugs
)
*
Nitrates
:
Diethylene glycol dinitrate (DEGDN)
Erythritol tetranitrate (ETN)
Ethylene glycol dinitrate (EGDN; nitroglycol)
Isosorbide mononitrate (ISMN)
Isosorbide dinitrate (ISDN)
Itramin tosilate
Mannitol hexanitrate
Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
NCX-466
NCX-2216
NCX-4016
NCX 4040
NCX-4215
Nicorandil
Nipradilol (K-351)
Nitrate (NO
−
3
)
Nitroatorvastatin (NCX-6560)
Nitroflurbiprofen (HCT-1026)
Nitrofluvastatin
Nitroglycerin (glyceryl trinitrate (GTN))
Nitropravastatin (NCX-6550)
Pentaerithrityl tetranitrate (PETN)
Propatylnitrate
Propylene glycol dinitrate (PGDN)
Sodium trioxodinitrate (Angeli's salt)
Tenitramine
Trolnitrate
Nitroso compounds
/
nitrites
:
Nitrite (NO
−
2
)
;
O-Nitroso compounds (
alkyl nitrites
):
Amyl nitrite (isoamyl nitrite, isopentyl nitrite)
Cyclohexyl nitrite
Ethyl nitrite
Hexyl nitrite
Isobutyl nitrite (2-methylpropyl nitrite)
Isopropyl nitrite
Methyl nitrite
n
-Butyl nitrite
Pentyl nitrite
tert
-Butyl nitrite
;
S-Nitroso compounds
(thionitrites):
LA810
S-Nitrosoalbumin (SNALB)
S-Nitrosated AR545C
S-Nitroso-N-acetylcysteine (SNAC)
S-Nitroso-N-acetylpenicillamine (SNAP)
S-Nitroso-N-valerylpenicillamine (SNVP)
S-Nitrosocaptopril (SNO-Cap)
S-Nitrosocysteine (SNC, CysNO, SNO-Cys)
S-Nitrosodiclofenac
S-Nitrosoglutathione (GSNO, SNOG)
SNO-t-PA
SNO-vWF
;
N-Nitroso compounds (e.g.,
nitrosamines
):
SIN-1A
Nitrosyl compounds:
Metal nitrosyl complexes
:
Roussin's black salt
Roussin's red salt
Sodium nitroprusside (SNP)
NONOates
(diazeniumdiolates):
Diethylamine/NO (DEA/NO)
Diethylenetriamine/NO (DETA/NO)
GLO/NO
JS-K
Methylamine hexamethylene methylamine/NO (MAHMA/NO)
PROLI/NO
Spermine/NO (SPER/NO)
V-PYRRO/NO
Heterocyclic compounds:
Furoxans
:
Furoxan
REC15/2739
;
Sydnonimines
:
Feprosidnine
Linsidomine (SIN-1)
Molsidomine (SIN-10)
Sydnonimine
Unsorted:
Cimlanod
FK-409
FR144220
FR146881
N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Enzyme
(
inhibitors
)
NOS
nNOS
*
3-Bromo-7-nitroindazole
3-Chloroindazole
3-Chloro-5-nitroindazole
5-Nitroindazole
6-Nitroindazole
7-Nitroindazole
A-84643
Aminoguanidine (pimagedine)
ARL-17477
Indazole
N
5
-(1-Iminoethyl)-L-ornithine (
L
-NIO)
N
ω
-Methyl-
L
-arginine (
L
-NMA)
N
ω
-Propyl-
L
-arginine (
L
-NPA)
Nitroarginine (NNA, NOARG)
Pentamidine isethionate
TRIM
iNOS
*
1-Amino-2-hydroxyguanidine
2-Ethylaminoguanidine
2-Iminopiperidine
1400W
AEITU
Aminoguanidine (pimagedine)
AMT
AR-C 102222
BYK-191023
Canavanine
Cindunistat (SD-6010)
EITU
IPTU
MITU
N
5
-(1-Iminoethyl)-
L
-ornithine (
L
-NIO)
N
6
-(1-Iminoethyl)-
L
-lysine (
L
-NIL)
N
ω
-Methyl-
L
-arginine (
L
-NMA)
Ronopterin (VAS-203)
TRIM
eNOS
*
Aminoguanidine (pimagedine)
N
5
-(1-Iminoethyl)-
L
-ornithine (
L
-NIO)
N
ω
-Methyl-
L
-arginine (
L
-NMA)
Nitroarginine (NNA, NOARG)
Unsorted
*
Asymmetric dimethylarginine (ADMA)
CKD-712
Guanidinoethyldisulfide (GED)
GW-273629
Indospicine
KD-7040
Nitroarginine methyl ester (NAME)
NCX-456
NXN-462
ONO-1714
VAS-2381
Nitrate reductase
Arginase
*
ABH
N
ω
-Hydroxy-
L
-arginine (NOHA)
chlorogenic acid
ginseng
epicatechin
ornithine
norvaline
lysine
alpha aminoacids
CAMK
*
Calmidazolium
W-7
GTPCH
Others
*
Precursors:
L
-Arginine
N
ω
-Hydroxy-
L
-arginine (NOHA)
Cofactors:
NADPH
FAD
FMN
Heme
BH
4
CaM
O
2
Ca
2+
Indirect/downstream NO modulators:
ACE inhibitors
/
AT-II receptor antagonists
(e.g.,
captopril
,
losartan
)
ET
B
receptor antagonists
(e.g.,
bosentan
)
L-Type calcium channel
blockers
(e.g.,
dihydropyridines
:
nifedipine
)
Nebivolol
(
beta blocker
)
PDE5 inhibitors
(e.g.,
sildenafil
)
non-selective PDE inhibitors (e.g.,
caffeine
)
PDE9 inhibitors (e.g.,
paraxanthine
)
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
Statins
(e.g.,
simvastatin
)
See also:
Receptor/signaling modulators
Category
:
Drug templates by receptor, channel, or pump