Molsidomine
Molsidomine is an orally active, long-acting vasodilator. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.
Etymology
The term "Molsidomine" is derived from the chemical name "morpholinylsydnonimine". "Morpholinyl" refers to the morpholine part of the molecule, "sydnonimine" refers to the sydnone imine part of the molecule.
Pharmacology
Molsidomine belongs to a group of medicines known as vasodilators. These drugs work by dilating (widening) blood vessels, making it easier for blood to flow through them. This helps to increase the supply of oxygen to the heart, which in turn reduces the heart's workload.
Clinical uses
Molsidomine is used for the prevention of angina pectoris. It is not useful in aborting an acute angina attack.
Side effects
Possible side effects of Molsidomine include headache, dizziness, hypotension, tachycardia, and gastrointestinal disturbances.
Contraindications
Molsidomine is contraindicated in patients with acute circulatory failure or hypotension.
Interactions
Molsidomine may interact with other vasodilators, antihypertensive agents, and sildenafil.
See also
References
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Contributors: Prab R. Tumpati, MD
