Luminal b breast carcinoma

Cancer that originates in the mammary gland

Breast cancer
Synonyms	N/A
Pronounce	N/A
Field	Oncology
Symptoms	A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on the breast
Complications
Onset
Duration
Types	N/A
Causes
Risks	Being female, obesity, lack of exercise, alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late in life or not at all, older age, prior breast cancer, family history of breast cancer, Klinefelter syndrome
Diagnosis	Tissue biopsy, Mammography
Differential diagnosis
Prevention
Treatment	Surgery, radiation therapy, chemotherapy, hormonal therapy, targeted therapy
Medication
Prognosis	Five-year survival rate ≈85% (US, UK)
Frequency	2.1 million affected as of 2018
Deaths	627,000 (2018)

A biologic subset of breast cancer defined by low to moderate expression of genes characteristic of luminal epithelial cells including estrogen receptor (ER), and high expression of GGH, LAPTMB4, and CCNE1. This subtype of breast cancer is associated with a good prognosis, although not as favorable as the luminal A subtype.

Breast cancer subtypes

There are four main female breast cancer subtypes, including the following in order of prevalence:

• HR+/HER2- ("Luminal A")
• HR-/HER2- ("Triple Negative")
• HR+/HER2+ ("Luminal B")
• HR-/HER2+ ("HER2-enriched")

Abbreviations

• HR stands for hormone receptor.
• HR+ means that tumor cells have receptors for the hormones estrogen or progesterone, which can promote the growth of HR+ tumors.
• HER2 stands for human epidermal growth factor receptor 2.
• HER2+ means that tumor cells make high levels of a protein called HER2/neu, which has been shown to be associated with certain aggressive types of breast cancer.

At a Glance

Age-Adjusted Rate of New Breast Cases per 100,000 Women, SEER 21 2013–2017

Subtype	New Cases
HR+/HER2-	87.0
HR-/HER2-	13.0
HR+/HER2+	13.3
HR-/HER2+	5.5
Unknown	9.7
Total	128.5

When all subtypes are combined, female breast cancer is fairly common.

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