Lifitegrast ophthalmic solution

What is Lifitegrast ophthalmic solution?

lifitegrast ophthalmic solution is a lymphocyte function-associated antigen-1 (LFA-1) antagonist supplied as a sterile, clear, colorless to slightly brownish-yellow colored, isotonic solution of lifitegrast with a pH of 7.0-8.0, and an osmolality range of 200-330 mOsmol/kg. The chemical name for lifitegrast is (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid. The molecular formula of lifitegrast is C29H24Cl2N2O7S and its molecular weight is 615.5 g/mol.

What are the uses of this medicine?

It is indicated for the treatment of the signs and symptoms of dry eye disease (DED).

How does this medicine work?

Lifitegrast binds to the integrin LFA-1, a cell surface protein found on leukocytes and blocks the interaction of LFA-1 with its cognate ligand intercellular adhesion molecule-1 (ICAM-1). ICAM-1 may be overexpressed in corneal and conjunctival tissues in DED. LFA-1/ICAM-1 interaction can contribute to the formation of an immunological synapse resulting in T-cell activation and migration to target tissues. In vitro studies demonstrated that lifitegrast may inhibit T-cell adhesion to ICAM-1 in a human T-cell line and may inhibit secretion of inflammatory cytokines in human peripheral blood mononuclear cells. The exact mechanism of action of lifitegrast in DED is not known.

Who Should Not Use this medicine?

It is contraindicated in patients with known hypersensitivity to lifitegrast .

Is this medicine FDA approved?

It is approved by US FDA on Jul 12, 2016.

What are the brand names and dosage forms of this medicine?

• Brand name: Xiidra; NDC codes: 0078-0911-05, 0078-0911-12, 0078-0911-94, 0078-0911-95.
• Ophthalmic solution containing lifitegrast 50 mg/mL (5%).

How should this medicine be used?

Instill one drop of Xiidra twice daily (approximately 12 hours apart) into each eye using a single-use container. Discard the single-use container immediately after using in each eye.

What special precautions should I follow?

Contact lenses should be removed prior to the administration of Xiidra and may be reinserted 15 minutes following administration.

What side effects can this medication cause?

• Hypersensitivity

What to do in case of emergency/overdose?

• In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

• Overdose related information is also available online at poisonhelp.org/help.
• In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Can this medicine be used in pregnancy?

There are no available data on Xiidra use in pregnant women to inform any drug-associated risks.

Can this medicine be used in children?

Safety and efficacy in pediatric patients below the age of 17 years have not been established.

What should I know about storage and disposal of this medication?

Store at 20°C to 25°C (68°F to 77°F). Store single-use containers in the original foil pouch.

• Dailymed label info on Lifitegrast ophthalmic solution
• FDA Lifitegrast ophthalmic solution

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