Hemosiderosis: Difference between revisions
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{{Infobox medical condition | |||
| name = Hemosiderosis | |||
| image = [[File:Hemosiderin1.jpg|250px]] | |||
| caption = Micrograph of hemosiderin-laden macrophages in the lung, as seen in [[pulmonary hemosiderosis]]. | |||
| field = [[Hematology]] | |||
| synonyms = | |||
| symptoms = [[Fatigue]], [[shortness of breath]], [[cough]], [[hemoptysis]] | |||
| complications = [[Pulmonary fibrosis]], [[liver damage]], [[heart failure]] | |||
| onset = Variable, depending on underlying cause | |||
| duration = Chronic | |||
| causes = Excessive [[iron]] accumulation, often due to repeated [[blood transfusions]], [[hemolytic anemia]], or [[chronic liver disease]] | |||
| risks = [[Thalassemia]], [[sickle cell disease]], [[alcoholic liver disease]] | |||
| diagnosis = [[Blood test]], [[liver biopsy]], [[MRI]] | |||
| differential = [[Hemochromatosis]], [[anemia]], [[chronic obstructive pulmonary disease]] | |||
| prevention = Avoidance of excessive iron intake, management of underlying conditions | |||
| treatment = [[Chelation therapy]], [[phlebotomy]], management of symptoms | |||
| prognosis = Variable, depends on extent of organ damage and response to treatment | |||
| frequency = Rare | |||
}} | |||
[[File:Kupffer_cell_with_hemosiderin_and_hepatocyte_with_lipofuscin.jpg|Kupffer cell with hemosiderin and hepatocyte with lipofuscin|thumb|left]] | |||
[[File:Kupffer_cell_with_hemosiderin_and_hepatocyte_with_lipofuscin,_iron_stain.jpg|Kupffer cell with hemosiderin and hepatocyte with lipofuscin, iron stain|thumb|left]] | |||
'''Hemosiderosis''' is a medical condition characterized by the accumulation of iron in the form of [[hemosiderin]] in various tissues of the body. This condition can occur as a result of excessive iron absorption, repeated blood transfusions, or as a secondary condition to other diseases. | '''Hemosiderosis''' is a medical condition characterized by the accumulation of iron in the form of [[hemosiderin]] in various tissues of the body. This condition can occur as a result of excessive iron absorption, repeated blood transfusions, or as a secondary condition to other diseases. | ||
== Causes == | == Causes == | ||
Hemosiderosis can be caused by several factors, including: | Hemosiderosis can be caused by several factors, including: | ||
* [[Iron overload]]: This can occur when the body absorbs too much iron from the food or supplements consumed. This excess iron is then stored in various organs, particularly the liver, heart, and pancreas. | * [[Iron overload]]: This can occur when the body absorbs too much iron from the food or supplements consumed. This excess iron is then stored in various organs, particularly the liver, heart, and pancreas. | ||
* [[Blood transfusions]]: Repeated blood transfusions can lead to an accumulation of iron in the body, as each unit of blood contains a significant amount of iron. | * [[Blood transfusions]]: Repeated blood transfusions can lead to an accumulation of iron in the body, as each unit of blood contains a significant amount of iron. | ||
* Secondary conditions: Certain diseases, such as [[thalassemia]], [[sickle cell anemia]], and [[myelodysplastic syndromes]], can lead to hemosiderosis as a secondary condition. | * Secondary conditions: Certain diseases, such as [[thalassemia]], [[sickle cell anemia]], and [[myelodysplastic syndromes]], can lead to hemosiderosis as a secondary condition. | ||
== Symptoms == | == Symptoms == | ||
The symptoms of hemosiderosis can vary depending on the organs affected. Common symptoms include: | The symptoms of hemosiderosis can vary depending on the organs affected. Common symptoms include: | ||
* [[Fatigue]] and weakness | * [[Fatigue]] and weakness | ||
* [[Abdominal pain]] | * [[Abdominal pain]] | ||
| Line 18: | Line 34: | ||
* [[Heart problems]], such as irregular heartbeat or heart failure | * [[Heart problems]], such as irregular heartbeat or heart failure | ||
* [[Endocrine problems]], such as hypothyroidism or diabetes | * [[Endocrine problems]], such as hypothyroidism or diabetes | ||
== Diagnosis == | == Diagnosis == | ||
Hemosiderosis is typically diagnosed through a combination of medical history, physical examination, and laboratory tests. These may include: | Hemosiderosis is typically diagnosed through a combination of medical history, physical examination, and laboratory tests. These may include: | ||
* [[Blood tests]]: These can help determine the level of iron in the body. | * [[Blood tests]]: These can help determine the level of iron in the body. | ||
* [[MRI]]: This imaging test can help identify iron deposits in the organs. | * [[MRI]]: This imaging test can help identify iron deposits in the organs. | ||
* [[Liver biopsy]]: This procedure involves taking a small sample of liver tissue for examination under a microscope. | * [[Liver biopsy]]: This procedure involves taking a small sample of liver tissue for examination under a microscope. | ||
== Treatment == | == Treatment == | ||
Treatment for hemosiderosis typically involves reducing the amount of iron in the body. This can be achieved through: | Treatment for hemosiderosis typically involves reducing the amount of iron in the body. This can be achieved through: | ||
* [[Phlebotomy]]: This procedure involves removing blood from the body to reduce the amount of iron. | * [[Phlebotomy]]: This procedure involves removing blood from the body to reduce the amount of iron. | ||
* [[Iron chelation therapy]]: This treatment involves taking medication to bind excess iron, which is then excreted from the body. | * [[Iron chelation therapy]]: This treatment involves taking medication to bind excess iron, which is then excreted from the body. | ||
== See also == | == See also == | ||
* [[Hemochromatosis]] | * [[Hemochromatosis]] | ||
* [[Iron deficiency anemia]] | * [[Iron deficiency anemia]] | ||
* [[Iron metabolism]] | * [[Iron metabolism]] | ||
{{stub}} | {{stub}} | ||
[[Category:Medical conditions]] | [[Category:Medical conditions]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Iron metabolism disorders]] | [[Category:Iron metabolism disorders]] | ||
Latest revision as of 21:18, 9 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Hemosiderosis | |
|---|---|
| |
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fatigue, shortness of breath, cough, hemoptysis |
| Complications | Pulmonary fibrosis, liver damage, heart failure |
| Onset | Variable, depending on underlying cause |
| Duration | Chronic |
| Types | N/A |
| Causes | Excessive iron accumulation, often due to repeated blood transfusions, hemolytic anemia, or chronic liver disease |
| Risks | Thalassemia, sickle cell disease, alcoholic liver disease |
| Diagnosis | Blood test, liver biopsy, MRI |
| Differential diagnosis | Hemochromatosis, anemia, chronic obstructive pulmonary disease |
| Prevention | Avoidance of excessive iron intake, management of underlying conditions |
| Treatment | Chelation therapy, phlebotomy, management of symptoms |
| Medication | N/A |
| Prognosis | Variable, depends on extent of organ damage and response to treatment |
| Frequency | Rare |
| Deaths | N/A |
Hemosiderosis is a medical condition characterized by the accumulation of iron in the form of hemosiderin in various tissues of the body. This condition can occur as a result of excessive iron absorption, repeated blood transfusions, or as a secondary condition to other diseases.
Causes[edit]
Hemosiderosis can be caused by several factors, including:
- Iron overload: This can occur when the body absorbs too much iron from the food or supplements consumed. This excess iron is then stored in various organs, particularly the liver, heart, and pancreas.
- Blood transfusions: Repeated blood transfusions can lead to an accumulation of iron in the body, as each unit of blood contains a significant amount of iron.
- Secondary conditions: Certain diseases, such as thalassemia, sickle cell anemia, and myelodysplastic syndromes, can lead to hemosiderosis as a secondary condition.
Symptoms[edit]
The symptoms of hemosiderosis can vary depending on the organs affected. Common symptoms include:
- Fatigue and weakness
- Abdominal pain
- Joint pain
- Heart problems, such as irregular heartbeat or heart failure
- Endocrine problems, such as hypothyroidism or diabetes
Diagnosis[edit]
Hemosiderosis is typically diagnosed through a combination of medical history, physical examination, and laboratory tests. These may include:
- Blood tests: These can help determine the level of iron in the body.
- MRI: This imaging test can help identify iron deposits in the organs.
- Liver biopsy: This procedure involves taking a small sample of liver tissue for examination under a microscope.
Treatment[edit]
Treatment for hemosiderosis typically involves reducing the amount of iron in the body. This can be achieved through:
- Phlebotomy: This procedure involves removing blood from the body to reduce the amount of iron.
- Iron chelation therapy: This treatment involves taking medication to bind excess iron, which is then excreted from the body.
