Felty's syndrome: Difference between revisions
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[[File:Swan_neck_deformity_in_a_65_year_old_Rheumatoid_Arthritis_patient-_2014-05-27_01-49.jpg|Swan neck deformity in a | {{SI}} | ||
{{Infobox medical condition | |||
| name = Felty's syndrome | |||
| image = [[File:Swan_neck_deformity_in_a_65_year_old_Rheumatoid_Arthritis_patient-_2014-05-27_01-49.jpg|thumb|Swan neck deformity in a patient with [[Rheumatoid arthritis]]]] | |||
| caption = Swan neck deformity in a patient with [[Rheumatoid arthritis]] | |||
| field = [[Rheumatology]] | |||
| synonyms = | |||
| symptoms = [[Rheumatoid arthritis]], [[splenomegaly]], [[neutropenia]] | |||
| complications = [[Infections]], [[anemia]], [[thrombocytopenia]] | |||
| onset = | |||
| duration = | |||
| types = | |||
| causes = Unknown, associated with [[Rheumatoid arthritis]] | |||
| risks = | |||
| diagnosis = Clinical evaluation, blood tests | |||
| differential = | |||
| prevention = | |||
| treatment = [[Methotrexate]], [[Granulocyte colony-stimulating factor]], [[Splenectomy]] | |||
| medication = | |||
| prognosis = | |||
| frequency = Rare | |||
| deaths = | |||
}} | |||
'''Felty's syndrome''' is a rare autoimmune disorder that is characterized by the triad of [[rheumatoid arthritis]], an enlarged [[spleen]] (splenomegaly), and a decreased white blood cell count (neutropenia). This condition is considered a severe subset of [[rheumatoid arthritis]] and can lead to increased susceptibility to infections. | |||
== Signs and Symptoms == | == Signs and Symptoms == | ||
The primary symptoms of Felty's syndrome include: | The primary symptoms of Felty's syndrome include: | ||
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* Splenomegaly: Enlargement of the [[spleen]], which can cause discomfort or pain in the upper left abdomen. | * Splenomegaly: Enlargement of the [[spleen]], which can cause discomfort or pain in the upper left abdomen. | ||
* Neutropenia: A lower than normal count of neutrophils, a type of white blood cell that helps fight infections, leading to increased risk of infections. | * Neutropenia: A lower than normal count of neutrophils, a type of white blood cell that helps fight infections, leading to increased risk of infections. | ||
Other symptoms may include: | Other symptoms may include: | ||
* [[Fatigue]] | * [[Fatigue]] | ||
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* [[Anemia]] | * [[Anemia]] | ||
* [[Lymphadenopathy]] (swollen lymph nodes) | * [[Lymphadenopathy]] (swollen lymph nodes) | ||
== Causes == | == Causes == | ||
The exact cause of Felty's syndrome is unknown, but it is believed to be related to the autoimmune nature of [[rheumatoid arthritis]]. Genetic factors and environmental triggers may also play a role in the development of the syndrome. | The exact cause of Felty's syndrome is unknown, but it is believed to be related to the autoimmune nature of [[rheumatoid arthritis]]. Genetic factors and environmental triggers may also play a role in the development of the syndrome. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of Felty's syndrome typically involves: | Diagnosis of Felty's syndrome typically involves: | ||
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* Imaging studies such as ultrasound or CT scan to assess spleen size | * Imaging studies such as ultrasound or CT scan to assess spleen size | ||
* Bone marrow biopsy in some cases to rule out other causes of neutropenia | * Bone marrow biopsy in some cases to rule out other causes of neutropenia | ||
== Treatment == | == Treatment == | ||
Treatment for Felty's syndrome focuses on managing the symptoms and underlying [[rheumatoid arthritis]]. Common treatments include: | Treatment for Felty's syndrome focuses on managing the symptoms and underlying [[rheumatoid arthritis]]. Common treatments include: | ||
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* [[Granulocyte colony-stimulating factor]] (G-CSF) to increase white blood cell count | * [[Granulocyte colony-stimulating factor]] (G-CSF) to increase white blood cell count | ||
* [[Splenectomy]] (surgical removal of the spleen) in severe cases | * [[Splenectomy]] (surgical removal of the spleen) in severe cases | ||
== Prognosis == | == Prognosis == | ||
The prognosis for individuals with Felty's syndrome varies. With appropriate treatment, many patients can manage their symptoms effectively. However, the condition can lead to serious complications, including recurrent infections and increased risk of [[lymphoma]]. | The prognosis for individuals with Felty's syndrome varies. With appropriate treatment, many patients can manage their symptoms effectively. However, the condition can lead to serious complications, including recurrent infections and increased risk of [[lymphoma]]. | ||
== See Also == | |||
== | |||
* [[Rheumatoid arthritis]] | * [[Rheumatoid arthritis]] | ||
* [[Autoimmune disease]] | * [[Autoimmune disease]] | ||
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* [[Disease-modifying antirheumatic drugs]] | * [[Disease-modifying antirheumatic drugs]] | ||
* [[Biologic response modifiers]] | * [[Biologic response modifiers]] | ||
== References == | == References == | ||
{{Reflist}} | {{Reflist}} | ||
{{Rheumatology}} | {{Rheumatology}} | ||
{{medicine-stub}} | {{medicine-stub}} | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
Latest revision as of 02:00, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC
| Felty's syndrome | |
|---|---|
 | |
| Synonyms | |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Rheumatoid arthritis, splenomegaly, neutropenia |
| Complications | Infections, anemia, thrombocytopenia |
| Onset | |
| Duration | |
| Types | |
| Causes | Unknown, associated with Rheumatoid arthritis |
| Risks | |
| Diagnosis | Clinical evaluation, blood tests |
| Differential diagnosis | |
| Prevention | |
| Treatment | Methotrexate, Granulocyte colony-stimulating factor, Splenectomy |
| Medication | |
| Prognosis | |
| Frequency | Rare |
| Deaths | |
Felty's syndrome is a rare autoimmune disorder that is characterized by the triad of rheumatoid arthritis, an enlarged spleen (splenomegaly), and a decreased white blood cell count (neutropenia). This condition is considered a severe subset of rheumatoid arthritis and can lead to increased susceptibility to infections.
Signs and Symptoms[edit]
The primary symptoms of Felty's syndrome include:
- Rheumatoid arthritis: Chronic inflammation of the joints, leading to pain, swelling, and potential joint deformity.
- Splenomegaly: Enlargement of the spleen, which can cause discomfort or pain in the upper left abdomen.
- Neutropenia: A lower than normal count of neutrophils, a type of white blood cell that helps fight infections, leading to increased risk of infections.
Other symptoms may include:
- Fatigue
- Weight loss
- Fever
- Anemia
- Lymphadenopathy (swollen lymph nodes)
Causes[edit]
The exact cause of Felty's syndrome is unknown, but it is believed to be related to the autoimmune nature of rheumatoid arthritis. Genetic factors and environmental triggers may also play a role in the development of the syndrome.
Diagnosis[edit]
Diagnosis of Felty's syndrome typically involves:
- Clinical evaluation of symptoms
- Blood tests to check for neutropenia and other abnormalities
- Imaging studies such as ultrasound or CT scan to assess spleen size
- Bone marrow biopsy in some cases to rule out other causes of neutropenia
Treatment[edit]
Treatment for Felty's syndrome focuses on managing the symptoms and underlying rheumatoid arthritis. Common treatments include:
- Disease-modifying antirheumatic drugs (DMARDs) such as methotrexate or sulfasalazine
- Biologic response modifiers like etanercept or infliximab
- Corticosteroids to reduce inflammation
- Granulocyte colony-stimulating factor (G-CSF) to increase white blood cell count
- Splenectomy (surgical removal of the spleen) in severe cases
Prognosis[edit]
The prognosis for individuals with Felty's syndrome varies. With appropriate treatment, many patients can manage their symptoms effectively. However, the condition can lead to serious complications, including recurrent infections and increased risk of lymphoma.
See Also[edit]
- Rheumatoid arthritis
- Autoimmune disease
- Neutropenia
- Splenomegaly
- Disease-modifying antirheumatic drugs
- Biologic response modifiers
References[edit]
<references group="" responsive="1"></references>
Rheumatologic diseases[edit]
Arthritis is often used to refer to any disorder that affects the joints. Rheumatic diseases usually affect joints, tendons, ligaments, bones, and muscles. Rheumatologic diseases usually affect joints, tendons, ligaments, bones, and muscles.
| Rheumatology and | Connective Tissue Diseases |
|---|---|
| Ankylosing spondylitis | Arthritis |
| Arthritis and Rheumatic diseases | Autoimmune diseases |
| Autoinflammatory diseases | Behçet’s disease |
| Bursitis | Giant cell arteritis |
| Gout | Juvenile arthritis |
| Knee problems | Lupus |
| Osteoarthritis | Polymyalgia rheumatica |
| Psoriatic arthritis | Reactive arthritis |
| Rheumatoid arthritis | Scleroderma |
| Sjögren’s syndrome | Systemic lupus erythematosus (Lupus) |
| Tendinitis | Rheumatologic diseases |
