Autoinflammatory diseases
Autoinflammatory diseases (pronunciation: /ˌɔːtoʊˌɪnfləˈmeɪtəri dɪˈziːzɪz/) are a group of medical conditions characterized by abnormal inflammation in the body that is not caused by pathogens or autoimmune diseases.
Etymology
The term "autoinflammatory" is derived from the Greek words "auto" meaning self, and "inflammatory" referring to the body's inflammatory response.
Definition
Autoinflammatory diseases are caused by genetic mutations that result in the body's immune system attacking its own cells and tissues, causing inflammation. Unlike autoimmune diseases, autoinflammatory diseases do not involve the production of autoantibodies or T-cells.
Types of Autoinflammatory Diseases
There are several types of autoinflammatory diseases, including:
- Familial Mediterranean Fever (FMF)
- Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS)
- Cryopyrin-Associated Periodic Syndromes (CAPS)
- Hyper IgD Syndrome (HIDS)
- Behcet's Disease
Symptoms
Common symptoms of autoinflammatory diseases include recurrent fever, rash, joint pain, and abdominal pain. The severity and frequency of these symptoms can vary greatly among individuals and between different types of autoinflammatory diseases.
Diagnosis
Diagnosis of autoinflammatory diseases typically involves a combination of medical history, physical examination, and laboratory tests. Genetic testing may also be used to confirm a diagnosis in some cases.
Treatment
Treatment for autoinflammatory diseases typically involves managing symptoms and preventing complications. This may include the use of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and biologic therapies.
See Also
External links
- Medical encyclopedia article on Autoinflammatory diseases
- Wikipedia's article - Autoinflammatory diseases
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