Disease-modifying antirheumatic drugs
Disease-modifying antirheumatic drugs (DMARDs)
Disease-modifying antirheumatic drugs (DMARDs) are a category of drugs commonly used in the treatment of rheumatoid arthritis. Pronounced as "dee-mardz", the term is derived from the words 'Disease', 'Modifying', 'Anti', 'Rheumatic', and 'Drugs'.
DMARDs work by reducing the body's immune response, which is overactive in diseases like rheumatoid arthritis. This helps to slow down the progression of the disease and reduce inflammation, thereby alleviating symptoms and preventing joint and organ damage.
Types of DMARDs
DMARDs can be classified into two main types: traditional DMARDs and biologic DMARDs.
- Traditional DMARDs: These include drugs like methotrexate, hydroxychloroquine, sulfasalazine, and leflunomide. They are often the first line of treatment for rheumatoid arthritis.
- Biologic DMARDs: These are newer drugs that target specific parts of the immune system. They include tumor necrosis factor inhibitors (TNF inhibitors), interleukin-1 inhibitors, interleukin-6 inhibitors, and T-cell inhibitors.
Side Effects
Like all medications, DMARDs can have side effects. These can include nausea, liver problems, lung infections, and an increased risk of other infections due to the suppression of the immune system. It's important for patients to discuss these potential side effects with their healthcare provider before starting treatment.
Related Terms
- Rheumatoid arthritis
- Methotrexate
- Hydroxychloroquine
- Sulfasalazine
- Leflunomide
- Tumor necrosis factor inhibitors
- Interleukin-1 inhibitors
- Interleukin-6 inhibitors
- T-cell inhibitors
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