Hypolipoproteinemia: Difference between revisions
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{{Infobox medical condition | |||
| name = Hypolipoproteinemia | |||
| synonyms = Low blood lipids | |||
| field = [[Endocrinology]] | |||
| symptoms = [[Fatigue]], [[muscle weakness]], [[neurological disorders]] | |||
| complications = [[Atherosclerosis]], [[coronary artery disease]] | |||
| onset = Varies | |||
| duration = Chronic | |||
| causes = [[Genetic disorders]], [[malnutrition]], [[hyperthyroidism]], [[liver disease]] | |||
| risks = [[Family history]], [[poor diet]], [[autoimmune diseases]] | |||
| diagnosis = [[Blood test]] | |||
| differential = [[Hyperlipoproteinemia]], [[hypothyroidism]], [[anemia]] | |||
| treatment = [[Dietary changes]], [[medication]], [[treating underlying conditions]] | |||
| medication = [[Statins]], [[fibrates]], [[niacin]] | |||
| frequency = Rare | |||
| deaths = Rarely directly fatal | |||
}} | |||
Hypolipoproteinemia refers to unusually low levels of fats ([[lipids]]) in the blood. | Hypolipoproteinemia refers to unusually low levels of fats ([[lipids]]) in the blood. | ||
=='''Cause'''== | =='''Cause'''== | ||
Low lipid levels may be caused by rare genetic conditions, or be a sign of another disorder such as overactive [[thyroid]], [[anemia]], undernutrition, cancer, chronic infection, or impaired absorption of foods from the digestive tract. Associated genetic disorders includes [[abetalipoproteinemia]], [[familial hypobetalipoproteinemia]], and [[chylomicron retention disease]]. | Low lipid levels may be caused by rare genetic conditions, or be a sign of another disorder such as overactive [[thyroid]], [[anemia]], undernutrition, cancer, chronic infection, or impaired absorption of foods from the digestive tract. Associated genetic disorders includes [[abetalipoproteinemia]], [[familial hypobetalipoproteinemia]], and [[chylomicron retention disease]]. | ||
=='''Signs and symptoms'''== | =='''Signs and symptoms'''== | ||
Signs and symptoms in the the genetic or familial form of hypolipoproteinemia vary. In hypobetalipoproteinemia the [[low density lipoprotein]] (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment. Other forms result in absent or near absent LDL levels and can cause serious symptoms in infancy and early childhood. | Signs and symptoms in the the genetic or familial form of hypolipoproteinemia vary. In hypobetalipoproteinemia the [[low density lipoprotein]] (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment. Other forms result in absent or near absent LDL levels and can cause serious symptoms in infancy and early childhood. | ||
The signs and symptoms associated with familial hypolipoproteinemia vary depending on the underlying cause. While some individuals may have mild signs or symptoms or no detectable associated health issues, others may have serious symptoms in infancy and early childhood. To view more detailed information on the associated signs and symptoms for the different genetic causes click on the links below: | The signs and symptoms associated with familial hypolipoproteinemia vary depending on the underlying cause. While some individuals may have mild signs or symptoms or no detectable associated health issues, others may have serious symptoms in infancy and early childhood. To view more detailed information on the associated signs and symptoms for the different genetic causes click on the links below: | ||
*[[Abetalipoproteinemia]] | *[[Abetalipoproteinemia]] | ||
*[[Familial hypobetalipoproteinemia]] | *[[Familial hypobetalipoproteinemia]] | ||
*[[Chylomicron retention disease]] | *[[Chylomicron retention disease]] | ||
=='''Diagnosis'''== | =='''Diagnosis'''== | ||
It can be diagnosed via blood study that identifies fat particles. The patient must fast overnight to prevent interference from fat in the blood due to food intake. The criteria for this (without the involvement of cholesterol-lowering drugs) are [[total cholesterol]] levels below 120 mg/dL and [[LDL cholesterol]] levels under 50 mg/dL. | It can be diagnosed via blood study that identifies fat particles. The patient must fast overnight to prevent interference from fat in the blood due to food intake. The criteria for this (without the involvement of cholesterol-lowering drugs) are [[total cholesterol]] levels below 120 mg/dL and [[LDL cholesterol]] levels under 50 mg/dL. | ||
=='''Treatment'''== | =='''Treatment'''== | ||
*Treatment for hypoproteinemia varies depending on the underlying cause and signs and symptoms present in each individual. | *Treatment for hypoproteinemia varies depending on the underlying cause and signs and symptoms present in each individual. | ||
*[[Vitamin E]] supplements have shown to help children with the deficiency. | *[[Vitamin E]] supplements have shown to help children with the deficiency. | ||
{{Lipidemias}} | {{Lipidemias}} | ||
[[Category:Lipid disorders]] | [[Category:Lipid disorders]] | ||
| Line 27: | Line 37: | ||
{{rarediseases}} | {{rarediseases}} | ||
{{stub}} | {{stub}} | ||
{{No image}} | |||
Latest revision as of 01:46, 4 April 2025
| Hypolipoproteinemia | |
|---|---|
| Synonyms | Low blood lipids |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fatigue, muscle weakness, neurological disorders |
| Complications | Atherosclerosis, coronary artery disease |
| Onset | Varies |
| Duration | Chronic |
| Types | N/A |
| Causes | Genetic disorders, malnutrition, hyperthyroidism, liver disease |
| Risks | Family history, poor diet, autoimmune diseases |
| Diagnosis | Blood test |
| Differential diagnosis | Hyperlipoproteinemia, hypothyroidism, anemia |
| Prevention | N/A |
| Treatment | Dietary changes, medication, treating underlying conditions |
| Medication | Statins, fibrates, niacin |
| Prognosis | N/A |
| Frequency | Rare |
| Deaths | Rarely directly fatal |
Hypolipoproteinemia refers to unusually low levels of fats (lipids) in the blood.
Cause[edit]
Low lipid levels may be caused by rare genetic conditions, or be a sign of another disorder such as overactive thyroid, anemia, undernutrition, cancer, chronic infection, or impaired absorption of foods from the digestive tract. Associated genetic disorders includes abetalipoproteinemia, familial hypobetalipoproteinemia, and chylomicron retention disease.
Signs and symptoms[edit]
Signs and symptoms in the the genetic or familial form of hypolipoproteinemia vary. In hypobetalipoproteinemia the low density lipoprotein (LDL) cholesterol levels are very low, yet people with this syndrome typically have no symptoms nor require treatment. Other forms result in absent or near absent LDL levels and can cause serious symptoms in infancy and early childhood. The signs and symptoms associated with familial hypolipoproteinemia vary depending on the underlying cause. While some individuals may have mild signs or symptoms or no detectable associated health issues, others may have serious symptoms in infancy and early childhood. To view more detailed information on the associated signs and symptoms for the different genetic causes click on the links below:
Diagnosis[edit]
It can be diagnosed via blood study that identifies fat particles. The patient must fast overnight to prevent interference from fat in the blood due to food intake. The criteria for this (without the involvement of cholesterol-lowering drugs) are total cholesterol levels below 120 mg/dL and LDL cholesterol levels under 50 mg/dL.
Treatment[edit]
- Treatment for hypoproteinemia varies depending on the underlying cause and signs and symptoms present in each individual.
- Vitamin E supplements have shown to help children with the deficiency.
| Inborn error of lipid metabolism: dyslipidemia (E78, 272.0–272.6) | ||||||||
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NIH genetic and rare disease info[edit]
Hypolipoproteinemia is a rare disease.
| Rare and genetic diseases | ||||||
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Rare diseases - Hypolipoproteinemia
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