Chemistry of ascorbic acid

L-Ascorbic acid

Ascorbic acid, commonly known as vitamin C, is a vital nutrient for humans and certain other animal species. It is a water-soluble vitamin and a potent antioxidant. Ascorbic acid is involved in various biochemical processes and is essential for the synthesis of collagen, the absorption of iron, and the maintenance of the immune system.

Structure

Ascorbic acid is a six-carbon compound related to glucose. It is a lactone that forms a five-membered ring structure. The chemical formula of ascorbic acid is C₆H₈O₆. The molecule contains multiple hydroxyl groups, which contribute to its solubility in water and its antioxidant properties.

Synthesis

In most plants and animals, ascorbic acid is synthesized from glucose via the uronic acid pathway. However, humans, along with some other species such as guinea pigs and certain primates, lack the enzyme L-gulonolactone oxidase required for this synthesis, making dietary intake essential.

Biochemical Role

Ascorbic acid acts as a cofactor in several enzymatic reactions. It is crucial for the hydroxylation of proline and lysine residues in collagen synthesis, which is necessary for the stability and strength of connective tissues. It also plays a role in the synthesis of neurotransmitters such as norepinephrine and serotonin.

Antioxidant Properties

Ascorbic acid is a powerful antioxidant that protects cells from damage by reactive oxygen species (ROS). It donates electrons to neutralize free radicals, thereby preventing oxidative stress and cellular damage. This property is particularly important in protecting DNA, proteins, and lipids from oxidative damage.

Dietary Sources

Ascorbic acid is abundant in many fruits and vegetables. Common sources include citrus fruits, strawberries, kiwi, bell peppers, broccoli, and spinach. The recommended daily intake varies by age, sex, and physiological status, such as pregnancy or lactation.

Deficiency

A deficiency in ascorbic acid leads to scurvy, a disease characterized by symptoms such as anemia, gum disease, and skin hemorrhages. Scurvy results from impaired collagen synthesis, leading to weakened connective tissues.

Related Compounds

Ascorbic acid is closely related to its oxidized form, dehydroascorbic acid, which can be reduced back to ascorbic acid in the body. Both forms are biologically active and contribute to the vitamin's overall antioxidant capacity.

See Also

• Vitamin C
• Antioxidant
• Collagen
• Scurvy
• L-gulonolactone oxidase
• Reactive oxygen species

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