Vasopressin receptor 1B

Vasopressin Receptor 1B (V1BR), also known as the Vasopressin 3 Receptor or AVPR1B, is a protein that in humans is encoded by the AVPR1B gene. This receptor is a member of the vasopressin/oxytocin family of G-protein-coupled receptors. The V1B receptor plays a critical role in the physiological responses to stress and in the regulation of water reabsorption in the kidneys.

Function

The V1B receptor is primarily found in the pituitary gland, where it is involved in the stimulation of adrenocorticotropic hormone (ACTH) release. ACTH, in turn, stimulates the adrenal gland to produce cortisol, a hormone essential for stress response and metabolism regulation. Besides its role in the pituitary gland, V1B receptors are also expressed in various peripheral tissues, although their functions in these locations are less well understood.

In the brain, V1B receptors have been implicated in social behavior, anxiety, and depression, suggesting a broader role in modulating stress-related emotional responses. The receptor's involvement in these processes makes it a potential target for the development of new treatments for mood disorders and stress-related conditions.

Clinical Significance

Mutations in the AVPR1B gene have been associated with familial central diabetes insipidus, a condition characterized by excessive thirst and dilute urine. Additionally, the V1B receptor has been studied as a potential target for drug development in the treatment of psychiatric disorders such as depression and anxiety, as well as in managing conditions related to stress and social dysfunction.

Pharmacological agents that act as antagonists to the V1B receptor are being explored for their therapeutic potential. These agents could offer new avenues for treatment by modulating the stress response and possibly improving outcomes in stress-related disorders.

See Also

• Vasopressin
• Vasopressin Receptor
• Adrenocorticotropic Hormone
• G-protein-coupled receptor

External Links

• AVPR1B Gene - NCBI Gene Database

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