OR13J1

OR13J1 is a protein that in humans is encoded by the OR13J1 gene. The protein is a member of the olfactory receptor family of G-protein-coupled receptors. They are located in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants.

Function

Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR13J1 gene is located on chromosome 1, specifically at 1q44. The gene spans approximately 1.1 kilobases and consists of a single coding exon. The OR13J1 gene is a member of the olfactory receptor family, which is the largest gene family in the human genome.

Clinical significance

While the specific clinical significance of OR13J1 is not yet fully understood, olfactory receptors such as OR13J1 are believed to have roles in various diseases and conditions. For example, alterations in the sense of smell (olfaction) can be an early sign of Parkinson's disease and Alzheimer's disease.

See also

• Olfactory receptor
• G protein-coupled receptor
• Olfaction

References

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