OR4K5

OR4K5 is a gene that encodes the olfactory receptor, family 4, subfamily K, member 5 protein in humans. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The protein encoded by the OR4K5 gene is an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes.

Gene

The OR4K5 gene is located on the chromosome 14 (14q11.1). It spans 1,093 base pairs and encodes a protein of 317 amino acids. The gene is expressed in the olfactory epithelium.

Clinical Significance

While the specific clinical significance of OR4K5 is not yet fully understood, olfactory receptors in general are thought to have roles in various human diseases such as cancer, metabolic and neurological diseases. Further research is needed to elucidate the specific roles and potential clinical applications of OR4K5.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Chromosome 14