OR52B4

OR52B4 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odor molecules, and is the largest gene family in mammals. The olfactory receptors interact with odorant molecules in the nose, initiating a neuronal response that triggers the perception of a smell.

The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

The OR52B4 gene is located on chromosome 11 in humans. It is expressed in the olfactory epithelium, a specialized tissue in the nose that is involved in smell. The protein encoded by this gene is thought to be involved in the detection of specific odorants.

Function

The OR52B4 gene encodes a protein that is a member of the olfactory receptor family. These proteins are responsible for detecting odor molecules and initiating a neuronal response that leads to the perception of smell. The protein encoded by the OR52B4 gene is thought to be involved in the detection of specific odorants.

Clinical significance

While the exact role of OR52B4 in disease is not well understood, it is thought that variations in this gene may be associated with differences in smell perception. This could potentially have implications for conditions such as anosmia (loss of smell), hyposmia (reduced ability to smell), and parosmia (distorted sense of smell).

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Hyposmia
• Parosmia

References

   This article is a medical stub. You can help WikiMD by expanding it!