OR5M1

OR5M1 is a gene that encodes a protein in humans. The protein is a member of the olfactory receptor family, a class of G protein-coupled receptors which are involved in the detection of smell.

Function

The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR5M1 gene is located on chromosome 1, specifically at 1q44. It spans a length of approximately 1.1 kilobases and contains one exon. The gene is expressed in the olfactory epithelium, a small region in the back of the nasal cavity that is responsible for detecting odors.

Protein Structure

The OR5M1 protein is a member of the olfactory receptor family, which is the largest family of G protein-coupled receptors. The protein is composed of 312 amino acids and has a molecular weight of approximately 35 kilodaltons. It contains seven transmembrane domains, a characteristic feature of G protein-coupled receptors.

Clinical Significance

While the exact role of OR5M1 in human health and disease is not fully understood, olfactory receptors such as OR5M1 are thought to play a role in various diseases and conditions. For example, alterations in olfactory receptor function have been implicated in conditions such as anosmia (loss of smell), and may also play a role in conditions such as obesity and cancer.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia