OR10R2

OR10R2

Symbol	OR10R2
HGNC ID	14857
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	1q23.1
Locus supplementary data	–

OR10R2 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are responsible for the detection of odor molecules and are a part of the G protein-coupled receptor (GPCR) superfamily. The olfactory receptor proteins are located in the olfactory epithelium of the nasal cavity.

Function

Olfactory receptors, such as OR10R2, interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. These receptors are part of a large family of GPCRs, which arise from single coding-exon genes. The olfactory receptor gene family is the largest in the human genome.

The OR10R2 gene is located on chromosome 1 and is expressed in the olfactory epithelium. The protein encoded by this gene is involved in the recognition and G protein-mediated transduction of odorant signals.

Structure

Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors. This structure is characteristic of GPCRs, which are involved in various signal transduction pathways.

Genomics

The OR10R2 gene is part of a cluster of olfactory receptor genes located on chromosome 1. The genomic organization of these genes is complex, with many pseudogenes interspersed among functional genes.

Clinical significance

Variations in olfactory receptor genes, including OR10R2, can affect an individual's sense of smell. These variations can lead to differences in odor perception and may be associated with certain olfactory disorders.

Research

Research on olfactory receptors like OR10R2 is ongoing, with studies focusing on understanding the molecular mechanisms of odor detection and the role of these receptors in olfactory system function.

See also

• Olfactory receptor family
• G protein-coupled receptor
• Chromosome 1

External links

• OR10R2 Gene - NCBI
• OR10R2 Gene - GeneCards